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Gene & Protein in Disease SCN7A is a protective factor in LUAD

Table 1. MicroRNA (miRNA) expression between lung
adenocarcinoma and normal tissues
miRNA Fold change P‑value False discovery rate
hsa-miR-21-5p 9.2 6.10e-101 1.60e-97
hsa-miR-93-5p 2.73 2.00e-11 3.60e-10
hsa-miR-570-3p 3.84 3.30e-06 3.10e-05
hsa-miR-590-3p 3.08 1.10e-23 6.10e-22
hsa-miR-182-3p 15.57 7.00e-05 0.00054
hsa-miR-17-3p 2 2.30e-09 3.30e-08
hsa-miR-576-5p 2.14 8.80e-07 9.00e-06
hsa-miR-577 124.3 1.30e-20 5.70e-19
hsa-miR-20a-5p 4.76 1.20e-26 7.20e-25
hsa-miR-155-5p 2.07 0.00048 0.0031
hsa-miR-556-5p 13.6 5.10e-06 4.60e-05
hsa-miR-331-5p 1.34 1.20e-06 1.20e-05
hsa-miR-106b-5p 1.38 1.20e-13 2.60e-12
hsa-miR-96-3p 15.09 0.00044 0.0029

A B

C D

Figure 12. Expression of SCN7A in pan-cancer tissues.

Figure 11. SCN7A as a protective factor in lung cancer cells. (A) SCN7A predict the prognoses of LUSC and OV besides LUAD.
mRNA expression between the control group and SCN7A overexpression Notably, SCN7A has been reported to be associated with
group. (B) Proliferation ability between the control group and SCN7A
[40]
overexpression group. (C and D) Migration ability between the control poor prognosis in LUSC . Our correlation analysis
group and SCN7A overexpression group (scale bar: 200μm). **P < 0.01, revealed a positive association between SCN7A expression
***P < 0.001, ****P < 0.0001. and immune cell infiltration to most tumor tissues. These
results suggest that SCN7A has significant research value
progression in colorectal and thyroid cancers [35-37] . miR- in pan-cancer.
21-5p contributes to lung cancer progression by inhibiting
SMAD family member 7 (SMAD7) expression , while In conclusion, our work demonstrated that the
[38]
miR-21-5p inhibitors can effectively suppress lung cancer underexpression of SCN7A predicts a poor prognosis in
progression . These studies suggest that the OTUD6B- LUAD, thus indicating that SCN7A is a potential target in
[39]
AS1-hsa-mir-21-5p-SCN7A axis may have an important the treatment of LUAD. Notably, OTUD6B-AS1 and miR-
role in LUAD. 21-5p are the ncRNAs that regulate SCN7A expression. The
We also identified mutations and the role of SCN7A role of SCN7A in LUAD prognosis needs to be validated by
in pan-cancer prognosis. We found that SCN7A could in vivo studies.

Volume 2 Issue 1 (2023) 11 https://doi.org/10.36922/gpd.363