Page 16 - GPD-2-1

Gene & Protein in Disease

REVIEW ARTICLE
Hydrogen sulfide donors and inhibitors in cancer

research: A state-of-the-art review

1†
Nazeer Hussain Khan , Ebenezeri Erasto Ngowi , Yan Li , Saadullah Khattak ,
1
3
2†
4
Yingshuai Zhao , Muhammad Shahid , Ujala Zafar , Irum Waheed ,
7
6
5
Fatima Khan , Razia Virk , Istaqlal Hussain , Jiebin Cao , Hongxia Liu ,
8
10
9
12
11
4
1
Zhihui Liu *, Dong-Dong Wu *, and Xin-Ying Ji *
12
1 Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical
Sciences, Henan University, Kaifeng, Henan 475004, China
2 Department of Biological Sciences, Faculty of Science, Dar es Salaam University College of
Education, Dar es Salaam 2329, Tanzania
3 Winship Cancer Institute of Emory University, 1365 Clifton Rd NE, Atlanta, GA 30322, USA
4 Department of General Practice, Henan Provincial People’s Hospital, People’s Hospital of
Zhengzhou University, Zhengzhou, Henan, 450003, China
5 Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti
Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia
6 Department of Materials science and engineering, Soft Matter Hybrid Laboratory Sungkyunkwan
University Natural Sciences Campus, Sungkyunkwan South Korea
7 Deprtment of Biological sciences, University of Agriculture Faisalabad, Faisalabad Pakistan
8 Department of Chemistry, University of Sargodha, Sargodha Pakistan
9 Department of Bio-Sciences, University of Wah, Rawalpindi Pakistan
10 Department of Biological sciences, Government College University Faisalabad, Faisalabad Pakistan
11 Center for Disease Control and Prevention, Erqi District, Zhengzhou, Henan 450001, China
12 School of Stomatology, Henan University, Kaifeng, Henan 475004, China

† These authors contributed equally
to this work.
*Corresponding authors: Abstract
Zhihui Liu
(lzhh@163.com) Hydrogen sulfide (H S), a gaseous biomolecule, is considered a key player in the
2
Dong-Dong Wu regulation of various essential cellular events. Normal physiology is determined by
(ddwubiomed2010@163.com)
Xin-Ying Ji the level of endogenous H S. Any alterations (upregulation and downregulation) to
2
(10190096@vip.henu.edu.cn) the level of endogenous H S may lead to illness, including the onset of tumorigenesis.
2
Citation: Khan NH, Ngowi EE, Over the past two decades, extensive research on the role of H S in cancer development
2
Li Y, et al., 2023, Hydrogen sulfide has affirmed the potential pharmacological means to suppress cancer progression by
donors and inhibitors in cancer either inhibiting H S synthesis in cells or exposing exogenously supplied H S donors
research: A state-of-the-art review. 2 2
Gene Protein Dis, 2(1):164. to treat different cancers. Some H S donors and inhibitors release H S or affect its
2
2
https://doi.org/10.36922/gpd.v2i1.164 synthesis. As a result, they have progressed through the development process into
Received: July 30, 2022 widespread clinical use and become increasingly important. The present study draws
Accepted: November 2, 2022 a detailed discussion on the types of H S donors and inhibitors and their role in cancer
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Published Online: December 15, 2022 research. We believe that this state-of-the-art review will empower the synthesis
Copyright: © 2022 Author(s). of H S-based chemopreventive drugs and promote the need for further in-depth
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This is an Open Access article exploration of the associations between H S and cancer treatments in clinical settings.
distributed under the terms of the 2
Creative Commons Attribution
License, permitting distribution, Keywords: Cancer; Diagnosis; H S donors; H S inhibitors; Hydrogen sulfide; Treatment
and reproduction in any medium, 2 2
provided the original work is
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with 1. Introduction
regard to jurisdictional claims in
published maps and institutional Hydrogen sulfide (H S) is a colorless, flammable gas with water-soluble properties
2
affiliations. and a rotten-egg odor. H S has historically been considered toxic and occupationally/
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Volume 2 Issue 1 (2023) 1 https://doi.org/10.36922/gpd.v2i1.164