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Gene & Protein in Disease Therapeutic opportunities in hydrogen sulfide for cancer research

https://doi.org/10.1016/j.heliyon.2019.e02244 219. Szczesny B, Módis K, Yanagi K, et al., 2014, AP39, a novel
mitochondria-targeted hydrogen sulfide donor, stimulates
210. Szadvari I, Hudecova S, Chovancova B, et al., 2019, Sodium/ cellular bioenergetics, exerts cytoprotective effects and
calcium exchanger is involved in apoptosis induced by H2S protects against the loss of mitochondrial DNA integrity in
in tumor cells through decreased levels of intracellular pH. oxidatively stressed endothelial cells in vitro. Nitric Oxide,
Nitric Oxide, 87: 1–9.
41: 120–130.
https://doi.org/10.1016/j.niox.2019.02.011
https://doi.org/10.1016/j.niox.2014.04.008
211. Lu S, Gao Y, Huang X, et al., 2014, GYY4137, a hydrogen 220. Xu S, Yang CT, Meng FH, et al., 2016, Ammonium
sulfide (H2S) donor, shows potent anti-hepatocellular tetrathiomolybdate as a water-soluble and slow-release hydrogen
carcinoma activity through blocking the STAT3 pathway. sulfide donor. Bioorg Med Chem Lett, 26(6): 1585–1588.
Int J Oncol, 44(4): 1259–1267.
https://doi.org/10.1016/j.bmcl.2016.02.005
https://doi.org/10.3892/ijo.2014.2305
221. Zhao YN, Chen LH, Yang XL, et al., 2020, Inhibition of
212. Yurinskaya MM, Garbuz DG, Afanasiev VN, et al., 2020, copper transporter-1 by ammonium tetrathiocarbolybdate
Effects of the hydrogen sulfide donor GYY4137 and in the treatment of pancreatic cancer. Sichuan Da Xue Xue
HSP70 protein on the activation of SH-SY5Y cells by Bao Yi Xue Ban, 51(5): 643–649.
lipopolysaccharide. Mol Biol (Mosk), 54(6): 1018–1028.
https://doi.org/10.12182/20200960101
https://doi.org/10.31857/S0026898420060142
222. Ryumon S, Okui T, Kunisada Y, et al., 2019, Ammonium
213. Hasegawa U, Tateishi N, Uyama H, et al., 2015, Hydrolysis‐ tetrathiomolybdate enhances the antitumor effect of
sensitive dithiolethione prodrug micelles. Macromol Biosci, cisplatin via the suppression of ATPase copper transporting
15(11): 1512–1522. beta in head and neck squamous cell carcinoma. Oncol
https://doi.org/10.1002/mabi.201500156 Rep, 42(6): 2611–2621.
214. Cai F, Xu H, Cao N, et al., 2020, ADT-OH, a hydrogen https://doi.org/10.3892/or.2019.7367
sulfide-releasing donor, induces apoptosis and inhibits the 223. Chisholm CL, Wang H, Wong AHH, et al., 2016,
development of melanoma in vivo by upregulating FADD. Ammonium tetrathiomolybdate treatment targets the
Cell Death Dis, 11(1): 33. copper transporter ATP7A and enhances sensitivity of
https://doi.org/10.1038/s41419-020-2222-9 breast cancer to cisplatin. Oncotarget, 7(51): 84439–84452.
https://doi.org/10.18632/oncotarget.12992
215. Dong Q, Yang B, Han JG, et al., 2019, A novel hydrogen
sulfide-releasing donor, HA-ADT, suppresses the growth 224. Chan N, Willis A, Kornhauser N, et al., 2017, Influencing
of human breast cancer cells through inhibiting the PI3K/ the tumor microenvironment: A phase II study of copper-
AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways. depletion using tetrathiomolybdate (TM) in patients with
Cancer Lett, 455: 60–72. breast cancer at high risk for recurrence and in preclinical
models of lung metastases. Clin Cancer Res, 23(3): 666–676.
https://doi.org/10.1016/j.canlet.2019.04.031
https://doi.org/10.1158/1078-0432.CCR-16-1326
216. Ma K, Liu Y, Zhu Q, et al., 2011, H2S donor, S-propargyl-
cysteine, increases CSE in SGC-7901 and cancer-induced 225. Li X, Li N, Huang L, et al., 2020, Is hydrogen sulfide a
mice: Evidence for a novel anti-cancer effect of endogenous concern during treatment of lung adenocarcinoma with
H2S? PLoS One, 6(6): e20525. ammonium tetrathiomolybdate? Front Oncol, 10: 234.
https://doi.org/10.1371/journal.pone.0020525 https://doi.org/10.3389/fonc.2020.00234
217. Wang W, Cheng J, Zhu Y, 2015, The JNK signaling pathway 226. Elsheikh W, Blackler RW, Flannigan KL, et al., 2014,
is a novel molecular target for S-propargyl-L-cysteine, Enhanced chemopreventive effects of a hydrogen
a naturally-occurring garlic derivatives: Link to its sulfide-releasing anti-inflammatory drug (ATB-346) in
anticancer activity in pancreatic cancer in vitro and in vivo. experimental colorectal cancer. Nitric Oxide, 41: 131–137.
Curr Cancer Drug Targets, 15(7): 613–623. https://doi.org/10.1016/j.niox.2014.04.006
https://doi.org/10.2174/1568009615666150602143943 227. De Cicco P, Panza E, Ercolano G, et al., 2016, ATB-346, a
218. Covarrubias AE, Lecarpentier E, Lo A, et al., 2019, AP39, novel hydrogen sulfide-releasing anti-inflammatory drug,
a modulator of mitochondrial bioenergetics, reduces induces apoptosis of human melanoma cells and inhibits
antiangiogenic response and oxidative stress in hypoxia- melanoma development in vivo. Pharmacol Res, 114: 67–73.
exposed trophoblasts: Relevance for preeclampsia https://doi.org/10.1016/j.phrs.2016.10.019
pathogenesis. Am J Pathol, 189(1): 104–114.
228. Kodela R, Chattopadhyay M, Velázquez-Martínez CA,
https://doi.org/10.1016/j.ajpath.2018.09.007 et al., 2015, NOSH-aspirin (NBS-1120), a novel nitric

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