Page 46 - GPD-2-1
P. 46
Gene & Protein in Disease Therapeutic opportunities in hydrogen sulfide for cancer research
2801–2808. glutathione and cystathionine β-synthase in ovarian
cancer treatment by selenium–chrysin polyurea dendrimer
https://doi.org/10.1016/j.cellsig.2014.08.023
nanoformulation. Nutrients, 11(10): 2523.
249. Wang YH, Huang JT, Chen WL, et al., 2019, Dysregulation
of cystathionine γ‐lyase promotes prostate cancer https://doi.org/10.3390/nu11102523
progression and metastasis. EMBO Rep, 20(10): e45986. 260. Chao C, Zatarain JR, Ding Y, et al., 2016, Cystathionine-β-
https://doi.org/10.15252/embr.201845986 synthase inhibition for colon cancer: Enhancement of the
efficacy of aminooxyacetic acid via the prodrug approach.
250. Kawahara B, Moller T, Hu-Moore K, et al., 2017, Attenuation Mol Med, 22(1): 361–379.
of antioxidant capacity in human breast cancer cells by
carbon monoxide through inhibition of cystathionine https://doi.org/10.2119/molmed.2016.00102
β-synthase activity: implications in chemotherapeutic 261. Szabo C, Coletta C, Chao C, et al., 2013, Tumor-
drug sensitivity. J Med Chem, 60(19): 8000–8010. derived hydrogen sulfide, produced by cystathionine-β-
https://doi.org/10.1021/acs.jmedchem.7b00476 synthase, stimulates bioenergetics, cell proliferation, and
angiogenesis in colon cancer. Proc Natl Acad Sci, 110(30):
251. Zhang L, Qi Q, Yang J, et al., 2015, An anticancer role of 12474–12479.
hydrogen sulfide in human gastric cancer cells. Oxid Med
Cell Longev, 2015: 636410. https://doi.org/10.1073/pnas.1306241110
https://doi.org/10.1155/2015/636410 262. Ascenção K, Dilek N, Augsburger F, et al., 2021,
Pharmacological induction of mesenchymal-epithelial
252. Wang L, Cai H, Hu Y, et al., 2018, A pharmacological transition via inhibition of H2S biosynthesis and
probe identifies cystathionine β-synthase as a new negative consequent suppression of ACLY activity in colon cancer
regulator for ferroptosis. Cell Death Dis, 9(10): 1005. cells. Pharmacol Res, 165: 105393.
https://doi.org/10.1038/s41419-018-1063-2 https://doi.org/10.1016/j.phrs.2020.105393
253. Sanokawa-Akakura R, Ostrakhovitch EA, Akakura S, et al., 263. Niu W, Chen F, Wang J, et al., 2018, Antitumor effect
2014, A H2S-Nampt dependent energetic circuit is critical of sikokianin C, a selective cystathionine β-synthase
to survival and cytoprotection from damage in cancer inhibitor, against human colon cancer in vitro and in vivo.
cells. PloS One, 9(9): e108537. Medchemcomm, 9(1): 113–120.
https://doi.org/10.1371/journal.pone.0108537 https://doi.org/10.1039/c7md00484b
254. Kim J, Hong SJ, Park JH, et al., 2009, Expression 264. Zhang M, Li J, Huang B, et al., 2020, Cystathionine β
of cystathionine β-synthase is downregulated in synthase/hydrogen sulfide signaling in multiple myeloma
hepatocellular carcinoma and associated with poor regulates cell proliferation and apoptosis. J Environ Pathol
prognosis. Oncol Rep, 21(6): 1449–1454. Toxicol Oncol, 39(3): 281–290.
https://doi.org/10.3892/or_00000373 https://doi.org/10.1615/JEnvironPatholToxicolOncol.2020034851
255. Zhang J, Xie Y, Xu Y, et al., 2011, Hydrogen sulfide 265. Govar AA, Törő G, Szaniszlo P, et al., 2020, 3‐Mercaptopyruvate
contributes to hypoxia-induced radioresistance on sulfurtransferase supports endothelial cell angiogenesis and
hepatoma cells. J Radiat Res, 52(5): 622–628. bioenergetics. Br J Pharmacol, 177(4): 866–883.
https://doi.org/10.1269/jrr.11004 https://doi.org/10.1111/bph.14574
256. Wang L, Han H, Liu Y, et al., 2018, Cystathionine 266. Augsburger F, Randi EB, Jendly M, et al., 2020, Role of
β-synthase induces multidrug resistance and metastasis in 3-mercaptopyruvate sulfurtransferase in the regulation
hepatocellular carcinoma. Curr Mol Med, 18(7): 496–506. of proliferation, migration, and bioenergetics in murine
https://doi.org/10.2174/1566524019666181211162754 colon cancer cells. Biomolecules, 10(3): 447.
257. Wang L, Yang Z, Wu Z, et al., 2020, Increased expression https://doi.org/10.3390/biom10030447
of cystathionine beta-synthase and chemokine ligand 21 267. Bantzi M, Augsburger F, Loup J, et al., 2021, Novel aryl-
is closely associated with poor prognosis in extrahepatic substituted pyrimidones as inhibitors of 3-mercaptopyruvate
cholangiocarcinoma. Medicine (Baltimore), 99(38): e22255. sulfurtransferase with antiproliferative efficacy in colon
https://doi.org/10.1097/MD.0000000000022255 cancer. J Med Chem, 64(9): 6221–6240.
258. Liu N, Lin X, Huang C, 2020, Activation of the reverse https://doi.org/10.1021/acs.jmedchem.1c00260
transsulfuration pathway through NRF2/CBS confers 268. Bronowicka-Adamska P, Bentke A, Lasota M, et al.,
erastin-induced ferroptosis resistance. Br J Cancer, 122(2): 2020, Effect of S-allyl–l-cysteine on MCF-7 cell line
279–292.
3-mercaptopyruvate sulfurtransferase/sulfane sulfur
259. Santos I, Ramos C, Mendes C, et al., 2019, Targeting system, viability and apoptosis. Int J Mol Sci, 21(3): 1090.
Volume 2 Issue 1 (2023) 31 https://doi.org/10.36922/gpd.v2i1.164

