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Gene & Protein in Disease                          Therapeutic opportunities in hydrogen sulfide for cancer research



                oxide-and hydrogen sulfide-releasing hybrid has enhanced   238.  Kashfi K, Chattopadhyay M, Kodela R, 2015, NOSH-
                chemo-preventive properties compared to aspirin, is   sulindac (AVT-18A) is a novel nitric oxide-and hydrogen
                gastrointestinal safe with all the classic therapeutic   sulfide-releasing hybrid that is gastrointestinal safe and
                indications. Biochem Pharmacol, 98(4): 564–572.    has potent anti-inflammatory, analgesic, antipyretic, anti-
                                                                   platelet, and anti-cancer properties. Redox Biol, 6: 287–296.
                https://doi.org/10.1016/j.bcp.2015.09.014
                                                                   https://doi.org/10.1016/j.redox.2015.08.012
            229.  Chattopadhyay M, Kodela R, Kashfi K, 2013, P09
                therapeutic potential of NOSH-aspirin, a dual nitric oxide-  239.  You J, Shi X, Liang H, et al., 2017, Cystathionine-γ-lyase
                and hydrogen sulfide-donating hybrid in colon cancer.   promotes process of breast cancer in association with
                Nitric Oxide, 31: S37–S38.                         STAT3 signaling pathway. Oncotarget, 8(39): 65677–65686.
                https://doi.org/10.1016/j.niox.2013.06.071         https://doi.org/10.18632/oncotarget.20057
            230.  Kashfi K, Chattopadhyay M, Kodela R, et al., 2013 NOSH‐  240.  You  J,  Ma  M,  Ye  J,  et al.,  2017,  Down-Regulation  of
                aspirin a Dual Nitric Oxide and Hydrogen Sulfide‐Releasing   Cystathionine-γ-lyase/H2S System Inhibits Cell Growth in
                Hybrid Reciprocally Regulates NF‐κB: S‐Nitrosylation vs S‐  Human Breast Cancer MDA-MB-231 Cells. In: BIO Web
                Sulfhydration. Hoboken, New Jersey: Wiley Online Library.  of Conferences. EDP Sciences.
            231.  Kashfi K, Borgo S, Williams JL,  et  al., 2005, Positional   241.  Chakraborty PK, Xiong X, Mustafi SB, et al., 2015, Role of
                isomerism markedly affects the growth inhibition of colon   cystathionine beta synthase in lipid metabolism in ovarian
                cancer cells by nitric oxide-donating aspirin in vitro and   cancer. Oncotarget, 6(35): 37367–37384.
                in  vivo. J Pharmacol Exp Ther, 312(3): 978–988.
                                                                   https://doi.org/10.18632/oncotarget.5424
                https://doi.org/10.1124/jpet.104.075994
                                                               242.  Liu Y, Wang L, Zhang X, et al., 2021, A novel cystathionine
            232.  Togashi  A,  Katagiri  T,  Ashida  S,  et al.,  2005,  Hypoxia-  γ-lyase inhibitor, I194496, inhibits the growth and
                inducible protein 2 (HIG2), a novel diagnostic marker for   metastasis of human TNBC via downregulating multiple
                renal cell carcinoma and potential target for molecular   signaling pathways. Sci Rep, 11(1): 1–13.
                therapy. Cancer Res, 65(11): 4817–4826.
                                                               243.  Ye F, Li X, Sun K, et al., 2020, Inhibition of endogenous
                https://doi.org/10.1158/0008-5472.CAN-05-0120      hydrogen  sulfide  biosynthesis  enhances  the  anti-cancer
                                                                   effect of 3, 3’-diindolylmethane in human gastric cancer
            233.  Huang Z, Fu J, Zhang Y, 2017, Nitric oxide donor-based
                cancer therapy: Advances and prospects.  J  Med Chem,   cells. Life Sci, 261: 118348.
                60(18): 7617–7635.                                 https://doi.org/10.1016/j.lfs.2020.118348
                https://doi.org/10.1021/acs.jmedchem.6b01672   244.  Yin P, Zhao C, Li Z, et al., 2012, Sp1 is involved in regulation
                                                                   of cystathionine  γ-lyase gene expression and biological
            234.  Jeong CH, Ryu H, Kim DH, et al., 2019, Piperlongumine
                induces cell cycle arrest via reactive oxygen species   function by PI3K/Akt pathway in human hepatocellular
                accumulation and IKKβ suppression in human breast   carcinoma cell lines. Cell Signal, 24(6): 1229–1240.
                cancer cells. Antioxidants (Basel), 8(11): 553.      https://doi.org/10.1016/j.cellsig.2012.02.003
                https://doi.org/10.3390/antiox8110553          245.  Pan Y, Ye S, Yuan D, et al., 2014, Hydrogen sulfide (H2S)/
                                                                   cystathionine  γ-lyase (CSE) pathway contributes to the
            235.  Chattopadhyay M, Kodela R, Santiago G,  et  al., 2020,
                NOSH-aspirin (NBS-1120) inhibits pancreatic cancer   proliferation of hepatoma cells. Mutat Res, 763–764: 10–18.
                cell growth in a xenograft mouse model: Modulation of      https://doi.org/10.1016/j.mrfmmm.2014.03.002
                FoxM1, p53, NF-κB, iNOS, caspase-3 and ROS. Biochem   246.  Pan Y, Zhou C, Yuan D, et al., 2016, Radiation exposure
                Pharmacol, 176: 113857.
                                                                   promotes hepatocarcinoma cell invasion through epithelial
                https://doi.org/10.1016/j.bcp.2020.113857          mesenchymal transition mediated by H2S/CSE pathway.
                                                                   Radiat Res, 185(1): 96–105.
            236.  Kodela  R,  Chattopadhyay  M,  Kashfi  K,  2013,  Synthesis  and
                biological activity of NOSH-naproxen (AVT-219) and NOSH-     https://doi.org/10.1667/RR14177.1
                sulindac (AVT-18A) as potent anti-inflammatory agents with   247.  Yang D, Li T, Li Y, et al., 2019, H2S suppresses indoleamine
                chemotherapeutic potential. Medchemcomm, 4(11): 1472–1481.
                                                                   2, 3-dioxygenase 1 and exhibits immunotherapeutic
                https://doi.org/10.1039/C3MD00185G                 efficacy in murine hepatocellular carcinoma.  J  Exp Clin
                                                                   Cancer Res, 38(1): 88.
            237.  Jia H, Ye J, You J, et al., 2017, Role of the cystathionine
                β-synthase/H2S system in liver cancer cells and the      https://doi.org/10.1186/s13046-019-1083-5
                inhibitory effect of quinolone-indolone conjugate QIC2 on   248.  Fan K, Li N, Qi J, et al., 2014, Wnt/β-catenin signaling
                the system. Oncol Rep, 37(5): 3001–3009.
                                                                   induces the transcription of cystathionine-γ-lyase, a
                https://doi.org/10.3892/or.2017.5513               stimulator of tumor in colon cancer. Cell Signal, 26(12):


            Volume 2 Issue 1 (2023)                         30                     https://doi.org/10.36922/gpd.v2i1.164
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