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Gene & Protein in Disease Pyroptosis-related LncRNAs in pediatric AML

in the presence of different PR-lncRNAs expressions. Funding
Recent studies have revealed that pyroptosis is a double‐
edged sword. On the one hand, pyroptosis-induced This work was supported by the Natural Science Foundation
inflammation facilitates the generation and maintenance of Henan Province, China (Grant No. 212300410402).
of an inflammatory microenvironment surrounding Conflict of interest
cancer cells, thus facilitating tumor development . On
[46]
the other hand, the acute activation of pyroptosis leads to The authors declare no conflicts of interest.
the infiltration of various immune cells, thus repressing
tumor development. Other studies have shown that many Author contributions
lncRNAs display a strong cell type-specific expression Conceptualization: Xinyu Chang
pattern in TME, especially in a variety of immune cell Formal analysis: Xinyu Chang, Guowei Zheng, Xiting Cao,
types . Hence, PR-lncRNAs, combining the dual effects Zhenwei Wang, Hao Zhu, Shuaijie Gao
[47]
of pyroptosis and lncRNAs, may result in a different Writing – original draft: Xinyu Chang
TME. Regrettably, with our study and previous research Writing – review & editing: Jie Lu, Yuanlin Xi
evidence, it is still impossible to conclude whether this
effect is positive or negative. At the end of this study, we Ethics approval and consent to participate
established a decision curve, inclusive of the risk score and Not applicable.
clinical parameters. It showed that the risk score was the
best predictor among various factors. Consent for publication
In this study, we built a prognostic signature and a Not applicable.
nomogram based on seven PR-lncRNAs to predict the
prognosis of pediatric AML patients and preliminarily Availability of data
explored the relationship between PR-lncRNAs and immune The transcriptome data and clinical data of 1474 AML
status, which have not been involved in the previous studies samples were retrieved from the TARGET database up to
before. Nevertheless, there are still some gaps in our research. March 1, 2022 (https://ocg.cancer.gov/programs/target).
First, the data we used in our analysis were obtained from a
public database; hence, the accuracy of the data cannot be References
verified. Second, our study did not include an external testing 1. Quessada J, Cuccuini W, Saultier P, et al., 2021, Cytogenetics
set; the prognostic signature was constructed and validated of pediatric acute myeloid leukemia: A review of the current
through the TARGET cohort. Last but not least, the potential knowledge (in eng). Genes (Basel), 12(6): 924.
relationship between the risk score and anticancer immunity
needs to be further explored. Given the limitations above, https://doi.org/10.3390/genes12060924
the conclusions drawn from our study still require a higher 2. Lejman M, Dziatkiewicz I, Jurek M, 2022, Straight to the
degree of detailed experimental verification. point-the novel strategies to cure pediatric AML (in eng).
Int J Mol Sci, 23(4): 1968.
5. Conclusion https://doi.org/10.3390/ijms23041968
Pyroptosis and lncRNAs play a critical role in the 3. Egan G, Chopra Y, Mourad S, et al., 2021, Treatment of acute
progression of pediatric AML, the prognosis of these myeloid leukemia in children: A practical perspective (in
patients, and the alteration of TME. Our research validated eng). Pediatr Blood Cancer, 68(7): e28979.
an original PR-lncRNAs signature that is independently https://doi.org/10.1002/pbc.28979
associated with OS. In addition, we identified the relevance
of the immune microenvironment in influencing pediatric 4. Kuwatsuka Y, Tomizawa D, Kihara R, et al., 2018, Prognostic
AML outcomes by analyzing the prognostic signature and value of genetic mutations in adolescent and young adults
immune profiles. The predictive value of the model needs with acute myeloid leukemia (in eng). Int J Hematol, 107(2):
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to be examined by accurate clinical data. Moreover, the
inherent mechanism by which PR-lncRNAs contribute https://doi.org/10.1007/s12185-017-2340-z
to antitumor immunity remains to be revealed in future 5. Hsu SK, Li CY, Lin IL, et al., 2021, Inflammation-related
studies. pyroptosis, a novel programmed cell death pathway, and its
crosstalk with immune therapy in cancer treatment (in eng).
Acknowledgments Theranostics, 11(18): 8813–8835.
None. https://doi.org/10.7150/thno.62521

Volume 2 Issue 1 (2023) 15 https://doi.org/10.36922/gpd.v2i1.230