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Gene & Protein in Disease Stem cell-based antimicrobial therapy

and repair, which is crucial in situations where infections cells to express AMPs or antibodies . In addition, stem
[14]
have severely harmed the host tissues . Delivering stem cells can be modified to specifically target infected host
[10]
cells to the infection site may make it possible to stimulate cells such as immune or endothelial cells. Numerous
tissue healing and restoration in addition to eradicating characteristics of stem cells make them particularly
the microbial invaders. pertinent for antimicrobial therapy. These include their

Antimicrobial resistance is a problem that stem cell capacity for regeneration and immunomodulation, as well
therapy may be able to address. Since stem cells can specialize as their capacity for differentiation and capacity to deliver
into specific cell types, they may be able to be engineered antimicrobial drugs to particular sites. These distinct
to produce antimicrobial medications that circumvent qualities make stem cells a promising source for the
[15]
resistance mechanisms. It has been demonstrated that a creation of fresh and efficient antimicrobial remedies .
synthetic AMP produced by MSCs can effectively eradicate The capacity to self-renew and differentiate into a range
drug-resistant bacteria in vitro and in animal models . of specialized cell types is a property of stem cells. They
[10]
Due to the tremendous potential of stem cells as a targeted are especially appealing for developing medicines that can
strategy against infections, there is a growing interest in repair or replace damaged tissues after infection due to
developing stem cell-based therapeutics for a variety of their regeneration capacity. Depending on their source and
infectious disorders. Due to their unique characteristics, lineage, stem cells can develop into a variety of cell types .
[16]
such as differentiation potential, immunomodulatory For instance, MSCs can differentiate into bone, cartilage,
abilities, and targeted delivery capacities, stem cells present and fat cells, whereas hematopoietic stem cells produce
a promising avenue for the development of novel and red and white blood cells. Neurons and glial cells, which
efficacious antimicrobial therapies. are significant cell types in the central nervous system, can
develop from neural stem cells.
2. Stem cell properties relevant to
It has been demonstrated that stem cells support tissue
antimicrobial therapy regeneration and restoration in the context of antimicrobial

Due to their capacity for differentiation, regenerative therapy. In animal models of pneumonia and lung injury,
and immunomodulatory abilities, and capacity to deliver stem cells have been shown to enhance lung function and
antimicrobials to particular areas, stem cells are highly promote tissue repair. Stem cells have been shown to lessen
advantageous for antimicrobial therapy. Stem cells may cerebral inflammation and promote neuronal regeneration
self-renew and develop into a number of different types of in animal models of bacterial meningitis. In addition, stem
specialized cells. Stem cells are particularly appealing for cells have the ability to secrete cytokines and growth factors
creating treatments that may replace or repair damaged that aid in tissue regeneration and repair . For instance,
[17]
tissues after an infection due to their capacity to regenerate . it has been shown that MSCs release molecules that
[11]
For example, stem cells have been shown to promote tissue encourage the growth of blood vessels and tissue healing.
regeneration in animal models of pneumonia and lung Depending on the type and stage of the infection as well
injuries. In addition to their regenerative capabilities, as the unique characteristics of the stem cells being used,
stem cells also possess immunomodulatory properties the impact of stem cells on tissue repair and regeneration
that can help regulate the immune system and accelerate may differ . Additional study is necessary to completely
[18]
the healing of infections. Cytokines and chemokines are understand stem cells’ ability to regenerate in the context
essential signaling molecules that regulate the immune of antimicrobial therapy.
response, and stem cells have the capacity to alter their The immunomodulatory abilities of stem cells can help
production . control the immune system and eliminate infections. Due
[12]
Stem cells can specialize into particular cell types that to these qualities, stem cells are particularly appealing for
can specifically target and eradicate microorganisms. It has the creation of anti-infection treatments that lessen tissue
been shown that MSCs can differentiate into macrophages, damage and inflammation. The production of cytokines
which are vital immune cells that can engulf and eliminate and chemokines, which are crucial signaling molecules
invasive infections . It has been shown that neural stem that control the immune response, can be changed by
[13]
cells can differentiate into neurons capable of combating stem cells [19,20] . By secreting substances that promote an
viral infections in the brain. Stem cells can be used to anti-inflammatory response, stem cells can reduce the
transport antimicrobial medications to specific body severity of infections and prevent tissue injury. In animal
regions. It may be possible to develop a highly targeted models of sepsis, MSC therapy has been shown to reduce
and localized therapy that may directly eradicate microbial inflammation and increase survival rates . In addition,
[21]
agents without hurting host tissues by engineering stem stem cells can inhibit immune cells that cause tissue injury

Volume 2 Issue 4 (2023) 3 https://doi.org/10.36922/gpd.1230