Page 8 - GPD-2-4
P. 8
Gene & Protein in Disease Glycomedicine
materiality [1,6] . Technically, the analysis of the glycome is Conflict of interest
demanding and necessitates the utilization of sophisticated
tools and techniques, such as mass spectrometry (MS), The author declares no conflict of interest.
liquid chromatography (LC), capillary electrophoresis (CE), References
nuclear magnetic resonance, microarray, cryo-electron
microscopy, and glycan imaging [1,2,5] . Each of these methods 1. Wang W, 2023, Glycomedicine: The current state of the art.
has its own drawbacks, leading to the application of Engineering, 26(7): 12–15.
complementary techniques for a comprehensive analysis of https://doi.org/10.1016/j.eng.2022.03.009
compounds, including gas chromatography-MS, LC-MS, 2. Wang W, Yang B, 2023, The glycome and glycomedicine.
and CE-MS [4,5] . Simultaneously, innovative technologies, Engineering, 26: 1–2.
automated workflows, and dedicated software are under
development [4,5] . Furthermore, the standardization of glycan https://doi.org/10.1016/j.eng.2023.05.007
analysis methods and the establishment of large-scale 3. Wang W, Jia JT, 1987, Phenotyping of phosphoglucomutase
glycan databases are critical steps for advancing the field. In (PGM1) subtypes in Chinese, with special reference to new
addition, ethical considerations surrounding glycan-based variant PGM1 China. Med Sci Law, 27: 280–282.
diagnostics and therapies must be addressed to ensure https://doi.org/10.1177/002580248702700408
responsible and equitable use.
4. Wang W, 2023, Editorial: Orthodox vs paradox: The roles
Glycomedicine represents a paradigm shift in our of glycomics, genetics and beyond in immunity, immune
understanding of health and disease. The intricate disorders and glycomedicine. Front Immunol, 14: 1305552.
language of glycans, once a mysterious code, is currently https://doi.org/10.3389/fimmu.2023.1305552
in the process of deciphering to unlock novel diagnostic 5. Wang Y, Adua E, Russell A, et al., 2016, Glycomics and
and therapeutic avenues [1,2,4,6] . As research in this field its application potential in precision medicine in China.
gains momentum, the promise of glycomedicine is poised Science/AAAS, 354(6316): 36–39.
to revolutionize health care, offering a sweet revolution
that could redefine our approach to precision medicine in https://doi.org/10.1126/science.354.6319.1601-b
the not-so-distant future. Navigating this exciting frontier 6. Ozdemir V, Arga KY, Aziz RK, et al., 2020, Digging deeper
underscores the paramount importance of collaboration into precision/personalized medicine: Cracking the sugar
among scientists, clinicians, and ethical stakeholders to code, the third alphabet of life, and sociomateriality of the
ensure that the benefits of glycomedicine are harnessed cell. OMICS, 24(2): 62–80.
responsibly for the betterment of global health [1,2,4,5] . https://doi.org/10.1089/omi.2019.0220
Volume 2 Issue 4 (2023) 2 https://doi.org/10.36922/gpd.2513

