Page 9 - GPD-2-4

Gene & Protein in Disease

REVIEW ARTICLE
Unleashing the potential of stem cells for

targeted antimicrobial treatment

Ali Yetgin *
1,2
1 Toros Agri Industry and Trade Co. Inc., Research and Development Center, Mersin, Turkey
2 Cukurova University, Institute of Nature and Applied Sciences, Department of Biotechnology, Adana,
Turkey

Abstract

Infectious diseases continue to pose a serious threat to human health as a result
of the spread of antibiotic resistance, underscoring the urgent need for new and
focused therapeutic approaches. Due to their regenerative and immunomodulatory
capabilities, stem cells have emerged as a potential source for the development of
antimicrobial therapies. This paper reviews the potential of stem cells as a targeted
strategy for combating infections, focusing on their ability to differentiate into
specific cell types that can directly target and eliminate microorganisms, as well
as their capacity to modulate the immune response and enhance host defenses.
The article discusses the challenges and opportunities associated with the clinical
implementation of antimicrobial therapies derived from stem cells. Among these
obstacles are the need for uniform protocols for cell isolation, expansion, and delivery,
as well as the significance of rigorous evaluations of safety and efficacy. Despite that,
the application of stem cells as a targeted antimicrobial approach holds significant
potential for the development of effective and enduring therapeutic interventions
for infectious diseases.
*Corresponding author:
Ali Yetgin
(ali1992yetgin@gmail.com) Keywords: Stem cells; Antimicrobial therapy; Targeted delivery; Regenerative medicine;
Host defense mechanisms
Citation: Yetgin A, 2023, Unleashing
the potential of stem cells for
targeted antimicrobial treatment.
Gene Protein Dis, 2(4): 1230.
https://doi.org/10.36922/gpd.1230 1. Introduction
Received: July 3, 2023 Infectious illnesses continue to pose a serious danger to global health, significantly
Accepted: September 20, 2023
Published Online: December 6, 2023 increasing the morbidity and mortality rates everywhere. Despite substantial advancements
in sanitation, antimicrobial medication research, vaccination, and infection management
Copyright: © 2023 Author(s).
This is an Open Access article over the past century, emerging and re-emerging pathogens continue to be a major
distributed under the terms of the concern. It has become more challenging to treat infections using currently available
Creative Commons Attribution medications as a result of the escalation of antibiotic resistance. The World Health
License, permitting distribution,
and reproduction in any medium, Organization estimates that at least 700,000 people die each year from drug-resistant
provided the original work is illnesses, and this fatality rate will reach 10 million by 2050 if no effective measures
properly cited. are taken to tackle this issue . To address the growing issue of antimicrobial resistance
[1]
Publisher’s Note: AccScience and improve outcomes for patients with infectious diseases, there is an urgent need for
Publishing remains neutral with novel and focused treatment alternatives. Due to their special qualities that make them
regard to jurisdictional claims in
published maps and institutional suitable for focused antimicrobial treatment, stem cell-based therapies have emerged as
affiliations. a viable approach to tackling this problem. Utilizing stem cells capacity for regeneration

Volume 2 Issue 4 (2023) 1 https://doi.org/10.36922/gpd.1230