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Gene & Protein in Disease                                          A One Health approach for avian influenza



            identifying novel viral targets. This approach involves   Anal Chim Acta. 2023;1251:341018.
            exploiting insights gained from studying immune       doi: 10.1016/J.ACA.2023.341018
            responses to the virus. The need for identifying new targets
            arises from the fact that most of the vaccines currently   2.   Charostad J, Rezaei Zadeh Rukerd M, Mahmoudvand S,
            available target hemagglutinin. However, hemagglutinin   et al. A comprehensive review of highly pathogenic avian
                                                                  influenza (HPAI) H5N1: An imminent threat at doorstep.
            exhibits  a  high  mutation  capacity  and  promotes  the   Travel Med Infect Dis. 2023;55:102638.
            adhesion of the virus to the carbohydrate receptors of the
            host cell.  Therefore, there is a crucial need to develop      doi: 10.1016/J.TMAID.2023.102638
                   29
            tailor-made multivalent vaccines perfectly matched to   3.   Wiramus S, Martin C. Rianimazione e influenza grave: Pandemia
            influenza virus strains with high pandemic potential.   influenzale a (H1N1). EMC Anest Rianim. 2013;18(2):1-9.
            For example, mRNA-lipid nanoparticle vaccines have      doi: 10.1016/S1283-0771(13)64502-8
            demonstrated the  ability to  induce  robust  immune
            responses in mice, rabbits, and ferrets, while also proving   4.   Xie R, Edwards KM, Wille M, et al. The episodic resurgence
            safe for use in humans.  Acknowledging the diverse range   of highly pathogenic avian influenza H5 virus.  Nature.
                              29
            of hosts susceptible to the etiological agent, improving   2023;622(7984):810-817.
            vaccination efforts in animal populations could effectively      doi: 10.1038/S41586-023-06631-2
            reduce the prevalence of circulating viruses. Consequently,   5.   Chatziprodromidou IP, Arvanitidou M, Guitian J,
            this approach could decrease the risk of environmental   Apostolou T, Vantarakis G, Vantarakis A. Global avian
            shedding and transmission to humans, in line with the   influenza outbreaks 2010-2016: A  systematic review of
            One Health concept.                                   their distribution, avian species and virus subtype. Syst Rev.
                                                                  2018;7(1):17.
            Acknowledgments
                                                                  doi: 10.1186/S13643-018-0691-Z
            None.
                                                               6.   Rzymski P. Avian influenza outbreaks in domestic cats:
            Funding                                               Another reason to consider slaughter-free cell-cultured
                                                                  poultry? Front Microbiol. 2023;14:1283361.
            This research received no external funding.           doi: 10.3389/FMICB.2023.1283361
            Conflict of interest                               7.   Mashaal D, Mahmoud SH, Müller C,  et  al. Differential
                                                                  impact of specific amino acid residues on the characteristics
            The authors declare no conflicts of interest.         of  Avian Influenza  viruses  in  Mammalian  systems.
                                                                  Pathogens. 2022;11(11):1385.
            Author contributions
                                                                  doi: 10.3390/PATHOGENS11111385
            Conceptualization: Mariachiara Paonessa, Bruno Tilocca,
               Paola Roncada                                   8.   Peacock  TP,  Sheppard  CM,  Lister  MG,  et al.  Mammalian
            Writing – original draft: Mariachiara Paonessa, Maira De   ANP32A and ANP32B proteins drive differential
               Salvo, Paola Roncada                               polymerase adaptations in Avian Influenza virus.  J  Virol.
                                                                  2023;97(5):e0021323.
            Writing – review & editing: Mariachiara Paonessa, Maira
               De Salvo, Bruno Tilocca, Paola Roncada             doi: 10.1128/JVI.00213-23
                                                               9.   Du R, Cui Q, Chen Z, Zhao X, Lin X, Rong L. Revisiting
            Ethics approval and Consent to Participate            influenza A virus life cycle from a perspective of genome
            Not applicable.                                       balance. Virol Sin. 2023;38(1):1-8.
                                                                  doi: 10.1016/J.VIRS.2022.10.005
            Consent for Publication
                                                               10.  Alexander DJ. An overview of the epidemiology of avian
            Not applicable.                                       influenza. Vaccine. 2007;25(30):5637-5644.
            Availability of Data                                  doi: 10.1016/J.VACCINE.2006.10.051
                                                               11.  Sonnberg S, Webby RJ, Webster RG. Natural history
            Not applicable.
                                                                  of highly pathogenic avian influenza H5N1.  Virus Res.
            References                                            2013;178(1):63-77.
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            Volume 3 Issue 1 (2024)                         4                        https://doi.org/10.36922/gpd.2327
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