Page 111 - GPD-3-2

Gene & Protein in Disease Inhibition of SOD1 in diseases

Funding doi: 10.1038/nrneurol.2011.150

None. 5. Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/
Zn superoxide dismutase gene are associated with familial
Conflict of interest amyotrophic lateral sclerosis. Nature. 1993;362(6415):59-62.

No conflicts of interest to declare. doi: 10.1038/362059a0
6. Sibilla C, Bertolotti A. Prion properties of SOD1 in
Author contributions amyotrophic lateral sclerosis and potential therapy. Cold

Conceptualization: Ayodele Sunday Alonge, Toluwase Spring Harbor Perspect Biol. 2017;9(10):a024141.
Hezekiah Fatoki, Iseoluwa Isaac Ajayi doi: 10.1101/cshperspect.a024141
Format analysis: Ayodele Sunday Alonge, Toluwase 7. Ligon LA, LaMonte BH, Wallace KE, Weber N, Kalb RG,
Hezekiah Fatoki, Iseoluwa Isaac Ajayi, Courage Dele Holzbaur EL. Mutant superoxide dismutase disrupts
Famusiwa, Oluwafijimi Adetuyi cytoplasmic dynein in motor neurons. Neuroreport.
Investigation: Ayodele Sunday Alonge, Toluwase Hezekiah 2005;16(6):533-536.
Fatoki, Iseoluwa Isaac Ajayi, Ibrahim Olabayode Saliu, doi: 10.1097/00001756-200504250-00002
Stanley Chukwuejim, Ohunene Esther Joseph
Methodology: Toluwase Hezekiah Fatoki, Ibrahim 8. Zhang F, Strom AL, Fukada K, Lee S, Hayward LJ, Zhu H.
Olabayode Saliu Interaction between familial amyotrophic lateral sclerosis
Writing – original draft: Ayodele Sunday Alonge, Toluwase (ALS)-linked SOD1 mutants and the dynein complex. J Biol
Hezekiah Fatoki, Iseoluwa Isaac Ajayi, Courage Dele Chem. 2007;282(22):16691-16699.
Famusiwa, Ohunene Esther Joseph doi: 10.1074/jbc.M609743200
Writing – review & drafting: Ayodele Sunday Alonge, 9. Elchuri S, Oberley TD, Qi W, et al. CuZnSOD deficiency
Toluwase Hezekiah Fatoki, Stanley Chukwuejim, leads to persistent and widespread oxidative damage and
Oluwafijimi Adetuyi hepatocarcinogenesis later in life. Oncogene. 2005;24(3):367-380.

Ethics approval and consent to participate doi: 10.1038/sj.onc.1208207
10. Busuttil RA, Garcia AM, Cabrera C, et al. Organ-specific
Not applicable.
increase in mutation accumulation and apoptosis rate in
Consent for publication CuZn-superoxide dismutase-deficient mice. Cancer Res.
2005;65(24):11271-11275.
Not applicable. doi: 10.1158/0008-5472.CAN-05-2980

Availability of data 11. Ho YS, Gargano M, Cao J, Bronson RT, Heimler I, Hutz RJ.
Reduced fertility in female mice lacking copper-zinc
Data used in this study are available on request from the superoxide dismutase. J Biol Chem. 1998;273(13):7765-7769.
corresponding author.
doi: 10.1074/jbc.273.13.7765
References 12. Blander G, De Oliveira RM, Conboy CM, Haigis M,
1. Fridovich I. Superoxide radical and superoxide dismutases. Guarente L. Superoxide dismutase 1 knock-down
Annu Rev Biochem. 1995;64:97-112. induces senescence in human fibroblasts. J Biol Chem.
2003;278(40):38966-38969.
doi: 10.1146/annurev.bi.64.070195.000525
doi: 10.1074/jbc.M307146200
2. Juarez JC, Manuia M, Burnett ME, et al. Superoxide
dismutase 1 (SOD1) is essential for H O -mediated oxidation 13. Somwar R, Erdjument-Bromage H, Larsson E, et al.
2
2
and inactivation of phosphatases in growth factor signaling. Superoxide dismutase 1 (SOD1) is a target for a small
Proc Natl Acad Sci U S A. 2008;105(20):7147-7152. molecule identified in a screen for inhibitors of the growth
of lung adenocarcinoma cell lines. Proc Natl Acad Sci U S A.
doi: 10.1073/pnas.0709451105 2011;108(39):16375-16380.
3. Ticozzi N, Tiloca C, Morelli C, et al. Genetics of familial doi: 10.1073/pnas.1113554108
amyotrophic lateral sclerosis. Arch Ital Biol. 2011;149(1):65-82.
14. Szklarczyk D, Gable AL, Nastou KC, et al. The STRING
doi: 10.4449/aib.v149i1.1262
database in 2021: Customizable protein-protein
4. Andersen PM, Al-Chalabi A. Clinical genetics of networks, and functional characterization of user-
amyotrophic lateral sclerosis: What do we really know? Nat uploaded gene/measurement sets. Nucleic Acids Res.
Rev Neurol. 2011;7(11):603-615. 2021;49(D1):D605-D612.

Volume 3 Issue 2 (2024) 10 doi: 10.36922/gpd.3042