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Gene & Protein in Disease                                                       Placenta, FASD, and soy



            Funding                                            5.   Sepe PS, Lahousse SA, Gemelli B, et al. Role of the aspartyl-
                                                                  asparaginyl-beta-hydroxylase gene  in neuroblastoma cell
            This research was supported by grants R01-AA-11431 and   motility. Lab Invest. 2002;82(7):881-891.
            R01-AA-28408 from the National Institute on Alcohol
            Abuse and Alcoholism at the National Institutes of Health.     doi: 10.1097/01.lab.0000020406.91689.7f
                                                               6.   Gundogan F, Elwood G, Greco D, et al. Role of aspartyl-
            Conflict of interest                                  (asparaginyl) beta-hydroxylase in placental implantation:
                                                                  Relevance to early pregnancy loss.  Hum Pathol.
            The authors declare that they have no competing interests.
                                                                  2007;38(1):50-59.
            Author contributions                                  doi: 10.1016/j.humpath.2006.06.005
            Conceptualization:  Fusun Gundogan, Suzanne M. de la   7.   Cantarini MC, De la Monte SM, Pang M, et al. Aspartyl-
               Monte                                              asparagyl beta hydroxylase over-expression in human
            Investigation: Fusun Gundogan, Ming Tong              hepatoma is linked to activation of insulin-like growth
            Methodology: Fusun Gundogan, Suzanne M. de la Monte   factor  and  notch  signaling  mechanisms.  Hepatology.
            Writing-original draft: Suzanne M. de la Monte        2006;44(2):446-457.
            Writing-review & editing: All authors                 doi: 10.1002/hep.21272
            Ethics approval and consent to participate         8.   Tong M, Ziplow J, Chen WC, Nguyen QG, Kim C, De la
                                                                  Monte SM. Motor function deficits following chronic
            The Lifespan IACUC of Rhode Island Hospital approved   prenatal  ethanol  exposure  are  linked  to  impairments  in
            the experimental use and treatment of Long Evans rats for   insulin/IGF, notch and wnt signaling in the  cerebellum.
            this research.                                        J Diabetes Metab. 2013;4(1):238.
                                                               9.   Tong M, Gonzalez-Navarrete H, Kirchberg T, et al. Ethanol-
            Consent for publication                               induced white matter atrophy is associated with impaired
            Not applicable.                                       expression of aspartyl-asparaginyl-β-hydroxylase (ASPH)
                                                                  and notch signaling in an experimental rat model. J Drug
            Availability of data                                  Alcohol Res. 2017;6:236033.

            Data  can  be  shared  on request  from  the  corresponding      doi: 10.4303/jdar/236033
            author.                                            10.  Dietrich B, Haider S, Meinhardt G, Pollheimer J, Knofler M.
                                                                  WNT and NOTCH signaling in human trophoblast
            References                                            development  and  differentiation.  Cell Mol Life Sci.
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            2.   Carter JJ, Tong M, Silbermann E,  et al. Ethanol impaired
               neuronal  migration  is associated with reduced aspartyl-  12.  De la Monte SM, Tong M, Lester-Coll N, Plater M Jr.,
               asparaginyl-beta-hydroxylase expression. Acta Neuropathol.   Wands JR. Therapeutic rescue of neurodegeneration in
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               doi: 10.1007/s00401-008-0377-z
                                                                  doi: 10.3233/jad-2006-10113
            3.   Ince N, De la Monte SM, Wands JR. Overexpression
               of  human  aspartyl  (asparaginyl)  beta-hydroxylase  is   13.  De la Monte SM, Tong M, Schiano I, Didsbury J. Improved
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               2000;60(5):1261-1266.                              with T3D-959 in an experimental model of sporadic
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            4.   Lawton M, Tong M, Gundogan F, Wands JR, De la Monte SM.
               Aspartyl-(asparaginyl) beta-hydroxylase, hypoxia-inducible      doi: 10.3233/JAD-160656
               factor-alpha and Notch cross-talk in regulating neuronal   14.  Pang M, De la Monte SM, Longato L,  et al. PPARdelta
               motility. Oxid Med Cell Longev. 2010;3(5):347-356.
                                                                  agonist attenuates alcohol-induced hepatic insulin
               doi: 10.4161/oxim.3.5.13296                        resistance and improves liver injury and repair. J Hepatol.


            Volume 3 Issue 2 (2024)                         10                               doi: 10.36922/gpd.3113
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