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Gene & Protein in Disease Comprehensive analysis of ZNF521/Zfp521

Funding acquisition: Yang An finger protein 521 in the control of growth, clonogenicity
Writing-original draft: Jiali Li, Yang An, Yanbing Pan and tumorigenic potential of medulloblastoma cells.
Writing-review & editing: Yang An Oncotarget. 2013;4(8):1280-1292.
doi: 10.18632/oncotarget.1176
Ethics approval and consent to participate
9. Mesuraca M, Galasso O, Guido L, et al. Expression profiling
Not applicable. and functional implications of a set of zinc finger proteins,
ZNF423, ZNF470, ZNF521, and ZNF780B, in primary
Consent for publication osteoarthritic articular chondrocytes. Mediators Inflamm.
Not applicable. 2014;2014:318793.
doi: 10.1155/2014/318793
Availability of data
10. Yang N, Wang L, Chen T, Liu R, Liu Z, Zhang L. ZNF521
Not applicable. which is downregulated by miR-802 suppresses malignant
progression of Hepatocellular Carcinoma through regulating
References Runx2 expression. J Cancer. 2020;11(19):5831-5839.
1. Bond HM, Mesuraca M, Amodio N, et al. Early hematopoietic doi: 10.7150/jca.45190
zinc finger protein-zinc finger protein 521: A candidate 11. Germano G, Morello G, Aveic S, et al. ZNF521 sustains
regulator of diverse immature cells. Int J Biochem Cell Biol. the differentiation block in MLL-rearranged acute myeloid
2008;40(5):848-854.
leukemia. Oncotarget. 2017;8(16):26129-26141.
doi: 10.1016/j.biocel.2007.04.006
doi: 10.18632/oncotarget.15387
2. Hesse E, Kiviranta R, Wu M, et al. Zinc finger protein 12. Fleenor CJ, Arends T, Lei H, et al. Zinc finger protein
521, a new player in bone formation. Ann N Y Acad Sci. 521 regulates early hematopoiesis through Cell-extrinsic
2010;1192:32-37.
mechanisms in the bone marrow microenvironment. Mol
doi: 10.1111/j.1749-6632.2009.05347.x Cell Biol. 2018;38(17):e00603-17.
3. Chiarella E, Aloisio A, Scicchitano S, Bond HM, Mesuraca M. doi: 10.1128/MCB.00603-17
Regulatory role of microRNAs targeting the transcription 13. Mega T, Lupia M, Amodio N, et al. Zinc finger protein
co-factor ZNF521 in normal tissues and cancers. Int J Mol 521 antagonizes early B-cell factor 1 and modulates the
Sci. 2021;22(16):8461.
B-lymphoid differentiation of primary hematopoietic
doi: 10.3390/ijms22168461 progenitors. Cell Cycle. 2014;10(13):2129-2139.
4. Hiratsuka T, Takei Y, Ohmori R, et al. ZFP521 contributes doi: 10.4161/cc.10.13.16045
to pre-B-cell lymphomagenesis through modulation of 14. Scicchitano S, Giordano M, Lucchino V, et al. The stem
the pre-B-cell receptor signaling pathway. Oncogene. cell-associated transcription co-factor, ZNF521, interacts
2016;35(25):3227-3238.
with GLI1 and GLI2 and enhances the activity of the Sonic
doi: 10.1038/onc.2015.385 hedgehog pathway. Cell Death Dis. 2019;10(10):715.
5. Mesuraca M, Chiarella E, Scicchitano S, et al. ZNF423 doi: 10.1038/s41419-019-1946-x
and ZNF521: EBF1 antagonists of potential relevance in 15. Shen S, Pu J, Lang B, McCaig CD. A zinc finger protein
B-lymphoid malignancies. Biomed Res Int. 2015;2015:165238.
Zfp521 directs neural differentiation and beyond. Stem Cell
doi: 10.1155/2015/165238 Res Ther. 2011;2(2):20.
6. Ohkubo N, Matsubara E, Yamanouchi J, et al. Abnormal doi: 10.1186/scrt61
behaviors and developmental disorder of hippocampus in 16. Shahbazi E, Moradi S, Nemati S, et al. Conversion of human
zinc finger protein 521 (ZFP521) mutant mice. PLoS One. fibroblasts to stably self-renewing neural stem cells with a
2014;9(3):e92848.
single zinc-finger transcription factor. Stem Cell Reports.
doi: 10.1371/journal.pone.0092848 2016;6(4):539-551.
7. Kiviranta R, Yamana K, Saito H, et al. Coordinated doi: 10.1016/j.stemcr.2016.02.013
transcriptional regulation of bone homeostasis by Ebf1 and 17. Zarei-Kheirabadi M, Hesaraki M, Shojaei A, Kiani S,
Zfp521 in both mesenchymal and hematopoietic lineages. Baharvand H. Generation of neural stem cells from adult
J Exp Med. 2013;210(5):969-985.
astrocytes by using a single reprogramming factor. J Cell
doi: 10.1084/jem.20121187 Physiol. 2019;234(10):18697-18706.
8. Spina R, Filocamo G, Iaccino E, et al. Critical role of zinc doi: 10.1002/jcp.28510

Volume 3 Issue 3 (2024) 10 doi: 10.36922/gpd.3260