Page 49 - GPD-3-3

Gene & Protein in Disease Phage therapy for Mycobacterium infections

therapy. There is an urgent need for breakthroughs in References
addressing the constraints associated with phage therapy, 1. Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance:
including the expansion of the host range of bacteriophages A global multifaceted phenomenon. Pathog Glob Health.
and the development of phage-derived gene products. In 2015;109(7):309-318.
light of the escalating issue of antibiotic resistance, which has
resulted in the emergence of superbugs that are impervious doi: 10.1179/2047773215y.0000000030
to existing antibiotics, phage therapy may represent a viable 2. Christaki E, Marcou M, Tofarides A. Antimicrobial resistance
alternative for combating resistant bacterial infections. in bacteria: Mechanisms, evolution, and persistence. J Mol
Evol. 2020;88(1):26-40.
Given the vast number of bacteriophages present on
the earth, their rational use could provide an important doi: 10.1007/s00239-019-09914-3
resource for combating infectious diseases. Bacteriophages 3. Prasad R, Gupta N, Banka A. Multidrug-resistant
exhibit considerable promise for precision therapy and tuberculosis/rifampicin-resistant tuberculosis: Principles of
the management of drug-resistant infections, particularly management. Lung India. 2018;35(1):78-81.
when enhanced through genetic engineering. However, doi: 10.4103/lungindia.lungindia_98_17
the ramifications of the extensive application of engineered
bacteriophages warrant careful consideration. Concurrently, 4. Global Tuberculosis Reports. WHO. Available from: https://
www.who.int/zh/news-room/fact-sheets/detail/tuberculosis
there is a need to identify novel mycobacteriophages [Last accessed on 2024 Aug 30].
that specifically target the most challenging pathogenic
mycobacteria and to explore alternative therapeutic 5. Global Tuberculosis Report. WHO. Available from: https://
approaches that maximize efficacy while minimizing www.who.int/zh/news-room/fact-sheets/detail/tuberculosis
adverse effects for patients. [Last accessed on 2024 Aug 31].
6. Wang H, Liu D, Zhou X. Effect of mycolic acids on host
Acknowledgments immunity and lipid metabolism. Int J Mol Sci. 2023;25(1):396.
None. doi: 10.3390/ijms25010396

Funding 7. Brives C, Pourraz J. Phage therapy as a potential solution
in the fight against AMR: Obstacles and possible futures.
This research was funded by the Key R&D and Palgrave Commun. 2020;6(1):100.
Promotion Projects of Henan Province (232102311139); doi: 10.1057/s41599-020-0478-4
China Postdoctoral Science Foundation (2021m690095);
and the National Innovation and Entrepreneurship 8. Olszak T, Latka A, Roszniowski B, Valvano MA, Drulis-
Kawa Z. Phage life cycles behind bacterial biodiversity. Curr
Training Program for College Students (20237003005 Med Chem. 2017;24(36):3987-4001.
and 20231022001).
doi: 10.2174/0929867324666170413100136
Conflict of interest 9. Arnau V, Díaz-Villanueva W, Mifsut Benet J, et al. Inference

The authors declare that they have no competing interests. of the life cycle of environmental phages from genomic
signature distances to their hosts. Viruses. 2023;15(5):1196.
Author contributions doi: 10.3390/v15051196

Conceptualization: Xinying Ji, Tieshan Teng 10. Erez Z, Steinberger-Levy I, Shamir M, et al. Communication
Supervision: Kunhou Yao between viruses guides lysis-lysogeny decisions. Nature.
Writing – original draft: Yuhan Wang 2017;541(7638):488-493.
Writing – review & editing: Sensen Hu, Yu Sun doi: 10.1038/nature21049

Ethics approval and consent to participate 11. Hay ID, Lithgow T. Filamentous phages: Masters of a
microbial sharing economy. EMBO Rep. 2019;20(6):e47427.
Not applicable.
doi: 10.15252/embr.201847427
Consent for publication 12. Hatfull GF. Mycobacteriophages. Microbiol Spectr. 2018;6(5).
Not applicable. doi: 10.1128/microbiolspec.GPP3-0026-2018

Availability of data 13. Dedrick RM, Mavrich TN, Ng WL, Hatfull GF. Expression
and evolutionary patterns of mycobacteriophage D29 and its
Not applicable. temperate close relatives. BMC Microbiol. 2017;17(1):225.

Volume 3 Issue 3 (2024) 10 doi: 10.36922/gpd.2935