Page 32 - GPD-3-4

Gene & Protein in Disease GLUT5 in cancer development and therapy

22. Tappy L. Metabolism of sugars: A window to the regulation 34. Cui Y, Tian J, Wang Z, et al. Fructose-induced mTORC1
of glucose and lipid homeostasis by splanchnic organs. Clin activation promotes pancreatic cancer progression through
Nutr. 2021;40:1691-1698. inhibition of autophagy. Cancer Res. 2023;83(24):4063-4079.
doi: 10.1016/j.clnu.2020.12.022 doi: 10.1158/0008-5472.CAN-23-0464
23. Nakagawa T, Lanaspa MA, Millan IS, et al. Fructose 35. Huang X, Fang J, Lai W, et al. IL-6/STAT3 axis activates
contributes to the Warburg effect for cancer growth. Cancer Glut5 to regulate fructose metabolism and tumorigenesis.
Metabol. 2020;8:16. Int J Biol Sci. 2022;18:3668-3675.
doi: 10.1186/s40170-020-00222-9 doi: 10.7150/ijbs.68990
24. Vaupel P, Multhoff G. Revisiting the Warburg effect: 36. Lu C, Ren C, Yang T, et al. Fructose-1, 6-bisphosphatase 1 interacts
Historical dogma versus current understanding. J Physiol. with NF-κB p65 to regulate breast tumorigenesis via PIM2
2021;599:1745-1757. induced phosphorylation. Theranostics. 2020;10:8606-8618.
doi: 10.1113/JP278810 doi: 10.7150/thno.46861
25. Ting KKY. Fructose-induced metabolic reprogramming of 37. Li M, Wang Z, Tao J, et al. Fructose-1,6-bisphosphatase 1
cancer cells. Front Immunol. 2024;15:1375461. dephosphorylates and inhibits TERT for tumor suppression.
Nat Chem Biol. 2024.
doi: 10.3389/fimmu.2024.1375461
doi: 10.1038/s41589-024-01623-3
26. Goncalves MD, Lu C, Tutnauer J, et al. High-fructose corn
syrup enhances intestinal tumor growth in mice. Science. 38. Li Y, Fu Y, Zhang Y, et al. Nuclear fructose-1,6-bisphosphate
2019;363(6433):1345-1349. inhibits tumor growth and sensitizes chemotherapy by
targeting HMGB1. Adv Sci (Weinh). 2023;10:e2203528.
doi: 10.1126/science.aat8515
doi: 10.1002/advs.202203528
27. Patra KC, Hay N. The pentose phosphate pathway and
cancer. Trends Biochem Sci. 2014;39(8):347-354. 39. Yang J, Dong C, Wu J, Liu D, Luo Q, Jin X. Fructose utilization
enhanced by GLUT5 promotes lung cancer cell migration
doi: 10.1016/j.tibs.2014.06.005 via activating glycolysis/AKT pathway. Clin Transl Oncol.
28. Liu H, Huang D, McArthur DL, Boros LG, Nissen N, Heaney 2023;25(4):1080-1090.
AP. Fructose induces transketolase flux to promote pancreatic doi: 10.1007/s12094-022-03015-2
cancer growth. Cancer Res. 2010;70(15):6368-6376.
40. Bu P, Chen KY, Xiang K, et al. Aldolase B-mediated fructose
doi: 10.1158/0008-5472.CAN-09-4615 metabolism drives metabolic reprogramming of colon
29. Lodge M, Scheidemantle G, Adams VR, et al. Fructose cancer liver metastasis. Cell Metab. 2018;27:1249-1262.
regulates the pentose phosphate pathway and induces an doi: 10.1016/j.cmet.2018.04.003
inflammatory and resolution phenotype in Kupffer cells. Sci
Rep. 2024;14:4020. 41. Kim J, Kang J, Kang YL, et al. Ketohexokinase-A acts as
a nuclear protein kinase that mediates fructose-induced
doi: 10.1038/s41598-024-54272-w metastasis in breast cancer. Nat Commun. 2020;11:5436.
30. Ghanem N, El-Baba C, Araji K, El-Khoury R, Usta J, doi: 10.1038/s41467-020-19263-1
Darwiche N. The pentose phosphate pathway in cancer: 42. Kang YL, Kim J, Kwak SB, et al. The polyol pathway and
Regulation and therapeutic opportunities. Chemotherapy. nuclear ketohexokinase A signaling drive hyperglycemia-
2021;66(5-6):179-191.
induced metastasis of gastric cancer. Exp Mol Med.
doi: 10.1159/000519784 2024;56:220-234.
31. Jin L, Zhou Y. Crucial role of the pentose phosphate pathway doi: 10.1038/s12276-023-01153-3
in malignant tumors (Review). Oncol Lett. 2019;17:4213-4221.
43. Ghanbari Movahed Z, Rastegari-Pouyani M,
doi: 10.3892/ol.2019.10112 Mohammadi MH, Mansouri K. Cancer cells change their
glucose metabolism to overcome increased ROS: One step
32. Jin C, Gong X, Shang Y. GLUT5 increases fructose utilization
in ovarian cancer. Onco Targets Ther. 2019;12:5425-5436. from cancer cell to cancer stem cell? Biomed Pharmacother.
2019;112:108690.
doi: 10.2147/ott.s205522
doi: 10.1016/j.biopha.2019.108690
33. Ma G, Liu S, Cai F, et al. Ketohexokinase-A deficiency
attenuates the proliferation via reducing beta-catenin in 44. Park GB, Jeong JY, Kim D. GLUT5 regulation by AKT1/3-
miR-125b-5p downregulation induces migratory activity
gastric cancer cells. Exp Cell Res. 2024;438:114038.
and drug resistance in TLR-modified colorectal cancer cells,
doi: 10.1016/j.yexcr.2024.114038 Carcinogenesis. 2020;41:1329-1340.

Volume 3 Issue 4 (2024) 11 doi: 10.36922/gpd.4171