Page 33 - GPD-3-4

Gene & Protein in Disease GLUT5 in cancer development and therapy

doi: 10.1093/carcin/bgaa074 progression. Sci Rep. 2017;7:9065.
45. Monzavi-Karbassi B, Hine RJ, Stanley JS, et al. Fructose doi: 10.1038/s41598-017-08835-9
as a carbon source induces an aggressive phenotype in 56. Chang YC, Chan YC, Chang WM, et al. Feedback regulation
MDA-MB-468 breast tumor cells. Int J Oncol. 2010;37:615-622.
of ALDOA activates the HIF-1α/MMP9 axis to promote
doi: 10.3892/ijo_00000710 lung cancer progression. Cancer Lett. 2017;403:28-36.
46. Zhang Y, Li Q, Huang Z, et al. Targeting glucose metabolism doi: 10.1016/j.canlet.2017.06.001
enzymes in cancer treatment: Current and emerging 57. Cui Y, Liu H, Wang Z, et al. Fructose promotes angiogenesis
strategies. Cancers (Basel). 2022;14:4568.
by improving vascular endothelial cell function and
doi: 10.3390/cancers14194568 upregulating VEGF expression in cancer cells. J Exp Clin
Cancer Res. 2023;42:184.
47. Gillet L, Roger S, Besson P, et al. Voltage-gated sodium
channel activity promotes cysteine cathepsin-dependent doi: 10.1186/s13046-023-02765-3
invasiveness and colony growth of human cancer cells. J Biol 58. Yoeli-Lerner M, Toker A. Akt/PKB signaling in cancer:
Chem. 2009;284:8680-8690.
A function in cell motility and invasion. Cell Cycle.
doi: 10.1074/jbc.M806891200 2006;5:603-605.
48. Brisson L, Driffort V, Benoist L, et al. Na(V)1.5 Na+ doi: 10.4161/cc.5.6.2561
channels allosterically regulate the NHE-1 exchanger and 59. Cheung M, Testa JR. Diverse mechanisms of AKT pathway
promote the activity of breast cancer cell invadopodia. J Cell
Sci. 2013;12:4835-4842. activation in human malignancy. Curr Cancer Drug Targets.
2013;13:234-244.
doi: 10.1074/jbc.M806891200
doi: 10.2174/1568009611313030002
49. Busco G, Cardone RA, Greco MR, et al. NHE1 promotes 60. Fang JH, Chen JY, Zheng JL, et al. Fructose metabolism in
invadopodial ECM proteolysis through acidification of the tumor endothelial cells promotes angiogenesis by activating
peri-invadopodial space. FASEB J. 2010;24:3903-3915.
AMPK signaling and mitochondrial respiration. Cancer Res.
doi: 10.1096/fj.09-149518 2023;83(8):1249-1263.
50. Magalhaes MAO, Larson DR, Mader CC, et al. Cortactin doi: 10.1158/0008-5472.CAN-22-1844
phosphorylation regulates cell invasion through a
pH-dependent pathway. J Cell Biol. 2011;195:903-920. 61. Peng CF, Yang P, Zhang DS, et al. KHK-A promotes
fructose-dependent colorectal cancer liver metastasis by
doi: 10.1083/jcb.201103045 facilitating the phosphorylation and translocation of PKM2.
51. Debreova M, Csaderova L, Burikova M, et al. CAIX regulates Acta Pharm Sin B. 2024;14:2959-2976.
invadopodia formation through both a pH-dependent doi: 10.1016/j.apsb.2024.04.024
mechanism and interplay with actin regulatory proteins. Int 62. Gao W, Li N, Li Z, Xu J, Su C. Ketohexokinase is involved
J Mol Sci. 2019;20:2745.
in fructose utilization and promotes tumor progression in
doi: 10.3390/ijms20112745 glioma. Biochem Biophys Res Commun. 2018;503:1298-1306.
52. Bundalo M, Zivkovic M, Culafic T, Stojiljkovic M, doi: 10.1016/j.bbrc.2018.07.040
Koricanac G, Stankovic A. Oestradiol treatment counteracts
the effect of fructose-rich diet on matrix metalloproteinase 63. Groenendyk J, Stoletov K, Paskevicius T, et al. Loss of the
9 expression and NFκB activation. Folia Biol (Praha). fructose transporter SLC2A5 inhibits cancer cell migration.
Front Cell Dev Biol. 2022;10:896297.
2015;61:233-240.
doi: 10.3389/fcell.2022.896297
53. LiK, Ying M, Feng D, et al. Fructose-1,6-bisphosphatase is a
novel regulator of Wnt/β-Catenin pathway in breast cancer. 64. Yang Y, Pu J, Yang Y. Glycolysis and chemoresistance in
Biomed Pharmacother. 2016;84:1144-1149. acute myeloid leukemia. Heliyon. 2024;10:e35721.
doi: 10.1016/j.biopha.2016.10.050 doi: 10.1016/j.heliyon.2024.e35721
54. Xu X, Zhang M, Xu F, Jiang S. Wnt signaling in breast cancer: 65. Ughachukwu P, Unekwe P. Efflux pump-mediated resistance
Biological mechanisms, challenges and opportunities. Mol in chemotherapy. Ann Med Health Sci Res. 2012;2:191-198.
Cancer. 2020;19:165.
doi: 10.4103/2141-9248.105671
doi: 10.1186/s12943-020-01276-5
66. Lopes-Rodrigues V, Di Luca A, Mleczko J, et al. Identification
55. Hsieh CL, Liu CM, Chen HA, et al. Reactive oxygen of the metabolic alterations associated with the multidrug
species-mediated switching expression of MMP-3 in resistant phenotype in cancer and their intercellular transfer
stromal fibroblasts and cancer cells during prostate cancer mediated by extracellular vesicles. Sci Rep. 2017;7:44541.

Volume 3 Issue 4 (2024) 12 doi: 10.36922/gpd.4171