Page 81 - GPD-3-4

Gene & Protein in Disease Interleukins-1β, interleukin-8, and the SARS-CoV-2

elderly individuals. In individuals aged ≥60 years, the and the need for ICU admissions. Therefore, our results
lethality rate was 55.4%, whereas it was 86.5% in those reinforce that vaccination promotes a decrease in severity,
who required ICU care. Ranzani et al. reported high mortality, and lethality in patients with SARS-CoV-2
33
34
mortality in hospitalized patients with COVID-19, even infection, thereby contributing to a significant improvement
in those patients aged <60 years, which reached rates of in their clinical prognosis.
31% in those not undergoing mechanical ventilation and
77% in those undergoing ICU treatment or mechanical Acknowledgments
ventilation. None.
The vaccinated group had a lower frequency of Funding
hospitalizations and maintenance in the ICU, similar
to the results reported by Orellana et al., in which This study was supported by the Sao Paulo Research
27
vaccinated patients showed a reduction in both the rate of Foundation (FAPESP) (case numbers: 2018/08481-1 and
hospitalizations and deaths from COVID-19. In patients 2021/12017-1).
aged 60 – 69 years, these authors confirmed hospitalization
rates of 60.5% and 39.5% in unvaccinated and vaccinated Conflict of interest
patients, with mortality rates of 81.8% and 18.2% in The authors declare they have no competing interests.
unvaccinated and vaccinated patients, respectively.
Author contributions
The expression of IL-8 was statistically significantly
greater in the ND group than in the other groups, with the Conceptualization: Laine Andreotti Almeida, Lucas T.
DVAC group showing the lowest expression. The other ILs Rasmussen
and receptors showed no statistically significant difference Formal analysis: Lucas T. Rasmussen
in their expression. Investigation: Laine Andreotti Almeida, Lucas T.
Rasmussen, Spencer L.M. Payão, Roger Labio
It is important to emphasize that this study has a few Methodology: Laine Andreotti Almeida, Lucas T.
methodological and technical limitations due to the Rasmussen, Spencer L.M. Payão, Roger Labio
pandemic itself. It was conducted at the time of the greatest Writing–original draft: Laine Andreotti
impact of SARS-CoV-2, amidst the care of thousands of Writing–review & editing: Laine Andreotti Almeida, Lucas
individuals, and during the rapid evolution of immunization T. Rasmussen, Mônica P. Santos, Mikaela Nagahara,
methods. One fact is that vaccination status is inherently Manuela S. Bueno
linked to the risk profile, which can affect groups. Numerous
doubts existed and still exist concerning COVID-19; hence, Ethics approval and consent to participate
the precision and generalizability of some data obtained at The study design consists of qualitative, cross-sectional,
that time can currently be considered a bias.
comparative, and randomized observational research
5. Conclusion and was conducted at the Genetics Laboratory of the
Hemocenter of the HC-FAMEMA, from September 2020
A detailed analysis of the data presented in this study to December 2021. All participants agreed to participate in
indicates that the presence of comorbidities is associated the study. This study was approved by the Research Ethics
with an increase in the expression of ILs genes, which Committee of Faculdade de Medicina de Marília (case
in turn is related to the greater severity of clinical signs number 4.414.477).
and symptoms. This resulted in a significant increase
in the number of hospitalizations and the need for ICU Consent for publication
admissions, as observed in the ND and DNVAC groups. Verbal consent was obtained from each of the subjects to
Altogether, our findings indicated that the severity publish the data.
of clinical manifestations in patients with COVID-19
reduced after administering at least two initial doses of the Availability of data
CoronaVac/Sinovac vaccine. Moreover, among patients Not applicable.
who received the minimum regimen of two doses of this
vaccine, a reduction in the frequency of most clinical References
manifestations was observed, especially those associated 1. Lu R, Zhao X, Li J, et al. Genomic characterisation and
with SARS. This reduction was accompanied by a epidemiology of 2019 novel coronavirus: Implications
considerable decrease in the number of hospitalizations for virus origins and receptor binding. Lancet.

Volume 3 Issue 4 (2024) 7 doi: 10.36922/gpd.4076