Page 96 - GPD-4-2

Gene & Protein in Disease

ORIGINAL RESEARCH ARTICLE
Expression of MXRA7 and its prognostic

significance in human bladder cancer

Mingjie Chen , Ting Wang 3 , and Yiqiang Wang *
1
1,2
1 Wisdom Lake Academy of Pharmacy, Xi’an Jiaotong-Liverpool University, Suzhou, China
2 Cancer Biology (Cancer Informatics) Programme, Department of Surgery and Cancer, Imperial
College London, London, United Kingdom
3 Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated
Hospital of Anhui Medical University, Hefei, China

Abstract

MXRA7, a gene associated with matrix remodeling, exhibits diverse expression profiles
across various cancers, including bladder cancer (BLCA). Previous studies have linked
elevated MXRA7 levels to poor clinical outcomes in multiple cancer types, although
its precise biological role remains unclear. In this study, bioinformatic analyses were
conducted using the Cancer Genome Atlas (TCGA) data to explore MXRA7 expression
levels in BLCA. Database for annotation, visualization, and integrated discovery
enrichment analysis was then employed to identify pathways associated with
differentially expressed genes (DEGs) between the high expression (MXRA7-H) and
low expression (MXRA7-L) groups. A least absolute shrinkage and selection operator
*Corresponding author: regression model was applied to MXRA7 and the DEGs in BLCA to generate a risk
Yiqiang Wang
(yiqiang.wang@xjtlu.edu.cn) score. Multifactor Cox regression analysis, conducted using statistical product and
service software automatically, was performed to identify reliable prognostic factors
Citation: Chen M, Wang T, Wang Y.
Expression of MXRA7 and its for patient survival. The results suggested that MXRA7 may play a role in invasion,
prognostic significance in human migration, and microenvironment remodeling in BLCA. Kaplan–Meier survival analysis
bladder cancer. Gene Protein Dis. revealed that higher MXRA7 expression was significantly associated with poorer
2025;4(2):6256.
doi: 10.36922/gpd.6256 survival outcomes in BLCA. Seven key factors – “Age”, “MXRA7”, “MXRA7 expression
level”, “Risk score”, “Tumor grade”, “Cancer status”, and “Clinical_N” – were identified as
Received: November 19, 2024
components of a robust predictive model, achieving an area under curve above 0.80.
1st revised: March 10, 2025 These findings suggest that MXRA7 could serve as a prognostic biomarker for BLCA
2nd revised: March 23, 2025 and may aid in the development of targeted therapeutic strategies.
Accepted: March 27, 2025
Keywords: MXRA7; Bladder cancer; Prognosis; Biomarker; Bioinformatics
Published online: April 17, 2025
Copyright: © 2025 Author(s).
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution 1. Introduction
License, permitting distribution,
and reproduction in any medium, Matrix Remodeling Associated 7 (MXRA7) was first identified in 2000 through a
1,2
provided the original work is pioneering bioinformatic study. So far, MXRA7 has been shown to play significant
properly cited. roles in various biological processes, including liver injury model, psoriasis and
3
4,5
Publisher’s Note: AccScience cutaneous injury models, as well as the differentiation of bone marrow mesenchymal
Publishing remains neutral with stem cells. From the perspective of malignancy, MXRA7 exhibits different expression
6
regard to jurisdictional claims in 7-9
published maps and institutional patterns across multiple tumors, including leukemia. Research indicates that MXRA7 is
-/+
10
affiliations. overexpressed in several cancers such as glioma with Pten genotype, colorectal cancer
Volume 4 Issue 2 (2025) 1 doi: 10.36922/gpd.6256