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Global Translational Medicine Effect of leptin on aortic dissection

intraperitoneal leptin injection may activate other signaling Writing – original draft: Ling Chen and YangXi
pathways, and leptin, as an upstream factor of the signaling Writing – review & editing: Ling Chen, YangXi, and Fan Xu
pathway, may affect the occurrence of dissection in other All authors read and approved the final manuscript.
ways. In a health study involving 12,203 men (screened by
ultrasound; 875 aneurysms ≥ 30 mm), aged 65 – 83 years, it Ethics approval and consent to participate
was found that there is no association between serum leptin Not applicable.
levels and AD . However, it is still unknown whether there
[88]
is a causal relationship between the systemic absorption of Consent for publication
leptin and the formation of dissecting aneurysms.
Not applicable.
The limitations of this study include the following:
(i) There are some differences in the detection of indicators Availability of data
considering that each research institute is located in a All data generated or analyzed during this study are
different region; in addition, data transformation was included in this published article.
carried out in this study for systematic analysis since most
studies reported in median and percentiles; (ii) there References
are inevitable differences in the level of experimental
conditions in different places, which has a certain impact 1. Bossone E, LaBounty TM, Eagle KA. 2018, Acute aortic
syndromes: diagnosis and management, an update. Eur
on the effect of the experiment.
Heart J, 39: 739–749d.
5. Conclusion https://doi.org/10.1093/eurheartj/ehx319
Based on current fundamental research and the results of 2. Zindovic I, Gudbjartsson T, Ahlsson A, et al., 2019,
this study, we have reason to believe that the local synthesis Malperfusion in acute type A aortic dissection: An update
of leptin can enlarge the aortic diameter and increase the from the Nordic Consortium for Acute Type A Aortic
dilation of the aortic wall. Although it is still impossible Dissection. J Thorac Cardiovasc Surg, 157: 1324–1333.e6.
to ascertain the fact that it can promote the formation of https://doi.org/10.1016/j.jtcvs.2018.10.134
dissection due to the lack of evidence, it can be concluded 3. Criado FJ. 2011, Aortic dissection: A 250-year perspective.
that the increase in dilation of the aortic wall can, to Tex Heart Inst J, 38: 694–700.
a certain extent, promote the formation of dissection,
especially in AD patients with underlying diseases, such as 4. Ma LY, Wang Z, Fan J, et al., 2022, China Cardiovascular
atherosclerosis, and that any event that results in vascular Health and Disease Report 2021 on the prevalence and
prevention of hypertension in China. Chin J General Pract,
wall instability will eventually lead to the occurrence of 25: 6.
AD. In conclusion, this study provides evidence that leptin
is a risk factor for AD. 5. Chen LW, Wu XJ, Dai XF, et al., 2016, Repair of acute
type A aortic dissection with ascending aorta replacement
Acknowledgments combined with open fenestrated stent graft placement. Ann
Thorac Surg, 101: 644–649.
None.
https://doi.org/10.1016/j.athoracsur.2015.07.060
Funding 6. Di S, Wang Y, Han L, et al., 2019, The intervention effect
This work was supported by Fujian Key Laboratory of of traditional Chinese medicine on the intestinal flora and
Cardio-Thoracic Surgery (Fujian Medical University). its metabolites in glycolipid metabolic disorders. Evid Based
Complement Altern Med, 2019: 2958920.
Conflict of interest https://doi.org/10.1155/2019/2958920

The paper has no financial interest in any individual 7. Saxena NK, Vertino PM, Anania FA, et al., 2007, Leptin-
or organization; it does not infringe on the intellectual induced growth stimulation of breast cancer cells involves
property rights of others. The manuscript and images are recruitment of histone acetyltransferases and mediator
original and have not been published before. All authors complex to CYCLIN D1 promoter via activation of Stat3.
have no conflicts of interest or financial ties to disclose. J Biol Chem, 282: 13316–13325.
https://doi.org/10.1074/jbc.M609798200
Author contributions
8. Otero M, Lago R, Lago F, et al., 2005, Signalling pathway
Conceptualization: Ling Chen and Liangwan Chen involved in nitric oxide synthase Type II activation in
Methodology: Ling Chen and Liangwan Chen chondrocytes: Synergistic effect of leptin with interleukin-1.

Volume 1 Issue 2 (2022) 8 https://doi.org/10.36922/gtm.v1i2.85