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Global Translational Medicine Effect of leptin on aortic dissection

Figure 2. Forest diagram of the effect of leptin on aortic diameter.

Figure 3. Forest diagram of the effect of leptin on aortic dilatation.

Figure 4. Results of sensitivity analysis (leptin enhanced group and leptin Figure 5. Egger’s test plot.
weakened group).
elastic fiber defect, and eventually result in the degradation
are arranged in a disorderly fashion, and type IV collagen of the basement membrane, thus providing a pathological
defects can be observed in the basement membrane of basis for the occurrence of AD .
[9]
smooth muscle cells (SMCs), along with other pathological
changes [9-11] . These pathological changes will increase the Abnormal glucose and lipid metabolism are mainly
compliance of the aortic wall; a high compliance can cause characterized by abdominal obesity and metabolic disorders
degeneration of SMCs in the middle layer, further lead to of lipid, glucose, and carbohydrate, which can cause

Volume 1 Issue 2 (2022) 5 https://doi.org/10.36922/gtm.v1i2.85