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Global Translational Medicine Editorial

is longer than 200 base pairs and does not code for any mechanisms of atherosclerosis. En face analyses of the aorta
proteins. LncRNAs perform various functions in the cell, and cross-sections of the aortic root are the two common
from nuclear compartmentation to epigenetic regulation modes for quantifying the severity of atherosclerosis
of gene expression and post-translational modification in mice. This article outlines the pros and cons of these
of proteins. This article sheds light on the mechanisms of two methods and provides suggestions to optimize the
the pathogenesis of IPF and suggests potential therapeutic quantification of atherosclerosis, thereby enhancing rigor
targets for IPF. and reproducibility in preclinical research, which means a
lot to the further translation to clinic.
[2]
The second article is about the application of
metabolomics in CVD. Succinate is generally considered We hope that our readers could be inspired by the
an important intermediate product of the tricarboxylic articles published in the inaugural volume of Global
acid cycle. Mounting studies have shown that succinate Translational Medicine. Moreover, we sincerely welcome
is related to the pathophysiology of CVD, such as submissions from our readers to publish new research,
atherosclerosis, acute aortic dissection, hypertension, insights, and novel results in the forthcoming issues of
myocardial ischemia-reperfusion injury, and heart failure. Global Translational Medicine.
It may represent a potential target or biomarker for CVD. It
has been demonstrated that succinate not only participates Conflict of interest
in various energy metabolic pathways but also plays an The author declares no conflict of interest.
important role in various pathophysiological activities as a
signaling molecule. Given the significance of metabolites in References
CVD, it is important to focus on the metabolic regulation 1. Zulkarneev SR, Zulkarneev RH, Korytina GF, et al.,
mechanism of succinate in CVD. This article outlines the 2022, Genetic and non-genetic risk factors of idiopathic
latest evidence pointing to the potential role of succinate in pulmonary fibrosis: A review. Glob Transl Med, 1: 107.
CVD, along with its mechanisms, and updates the current https://doi.org/10.36922/gtm.v1i2.107
understanding on the role of succinate in CVD, which is
of great significance not only for clinical diagnosis and 2. Shan W, Cui H, Xu Y, et al., 2022, Succinate metabolism in
treatment but also for basic research. cardiovascular diseases. Glob Transl Med, 1: 160.
https://doi.org/10.36922/gtm.v1i2.160
The third article introduces two preclinical murine
[3]
models used in the basic research of atherosclerosis. 3. Chen H, Howatt DA, Franklin MK, et al., 2002, A mini-review
Atherosclerosis is a leading cause of morbidity and on quantification of atherosclerosis in hypercholesterolemic
mortality in many countries. Mice are the most frequently mice. Glob Transl Med, 1: 72.
used animal model to study the pathogenesis and molecular https://doi.org/10.36922/gtm.v1i1.76

Volume 1 Issue 2 (2022) 2 https://doi.org/10.36922/gtm.v1i2.315