Page 9 - GTM-1-2

Global Translational Medicine

ORIGINAL RESEARCH ARTICLE
Effect of leptin on aortic dissection

Ling Chen , Yang Xi , Fan Xu , and Liangwan Chen *
1,2
1,2
1,2
1,2
1 Department of Cardiac Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001,
People’s Republic of China
2 Fujian Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fuzhou, Fujian
350001, People’s Republic of China

Abstract

The most important clinical features of aortic dissection (AD) are its acute onset,
rapid progress, and high fatality rate. The exact pathogenesis of AD is unclear,
and the focus of current research on the mechanism of AD has been primarily on
hypertension and changes in metalloproteinases, among which leptin plays an
important role. The purpose of this study is to evaluate the effect of leptin on AD.
We conducted a computerized literature search on animal studies related to leptin
and dissecting aortic aneurysm in PubMed, EMBASE, Cochrane Library, MEDLINE,
and other databases from their inception to present. Meta-analysis was conducted
to compare the changes in aortic diameter, aortic dilatation, and the incidence of AD
in mice under the local intervention of leptin or leptin antagonist (LepA). A total of
four studies were included, involving five batches of animal experiments. According
to the results of the meta-analysis, the increase in local leptin content led to the
enlargement of aortic diameter (relative risk [RR] = 0.18; 95% confidence interval [CI]:
0.09 – 0.27; P < 0.0001) and increased aortic dilatation (RR = 0.11; 95% CI: 0.01 – 0.22;
P < 0.0001). This meta-analysis showed that local leptin administration increased the
aortic diameter and aortic dilatation. However, due to high heterogeneity between
the results, it is difficult to draw a clear conclusion on the effect of leptin on AD.
*Corresponding author:
Liangwan Chen
(chengliangwan@tom.com)
Keywords: Leptin; Aortic dissection; Leptin antagonist
Citation: Chen L, Xi Y, Xu F,
et al., 2022, Effect of leptin on aortic
dissecting. Global Transl Med, 1(2): 85.
https://doi.org/10.36922/gtm.v1i2.85 1. Introduction
Received: May 6, 2022
Accepted: November 14, 2022 Aortic dissection (AD) is an acute cardiovascular disease that is caused by high-speed
Published Online: December 9,
2022 blood flow impacting the aortic intima, resulting in a break or tear in the middle layer
of the aortic wall, and separating the inner and outer layers, thus forming a true lumen
Copyright: © 2022 Author(s). (the original aortic cavity) and a false lumen (a gap formed between the inner and outer
This is an Open Access article
distributed under the terms of the layers by the tearing of the middle layer). AD patients rely on the outer structure of the
Creative Commons Attribution torn aortic wall to withstand the aortic pressure that should be borne by the entire aortic
License, permitting distribution,
and reproduction in any medium, wall. This outer structure is vulnerable to rupture, which may lead to death within a short
provided the original work is period of time. If a patient is not diagnosed and treated in time, the mortality rate within
properly cited. 1 week is about 37%, while the mortality rate within 2 weeks is as high as 75% [1,2] . There
Publisher’s Note: AccScience are about 12 new cases of AD in developed countries per million people per year [1-3] , and
Publishing remains neutral with up to date, no large-scale epidemiological studies have been reported in China. With the
regard to jurisdictional claims in
published maps and institutional improvement of living standards and the progress of diagnostic technology, the number
[4]
affiliations. of AD patients in China is increasing at an explosive rate .

Volume 1 Issue 2 (2022) 1 https://doi.org/10.36922/gtm.v1i2.85