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Global Translational Medicine

EDITORIAL
Inaugural editorial: A new platform dedicated to

promote bench-to-bedside translation

Lemin Zheng *
†
The Institute of Cardiovascular Sciences, Peking University, Beijing, China

We are pleased to introduce you to the inaugural volume of Global Translational
Medicine, a new journal under AccScience Publishing (Singapore) Pte. Ltd. Global
Translational Medicine is a quarterly journal that focuses on medicine, biological
sciences, and biomaterials engineering. Global Translational Medicine provides a
platform to fill the gaps in preclinical and inter-disciplinary research, to promote
clinical translation of scientific research results, and to contribute to the conception
of new and improved preventive measures as well as diagnostic and therapeutic
techniques of diseases.

Translational medicine is a branch of medical research which aims to bridge basic
research and clinical application. The main focus of Global Translational Medicine is to
break down the barriers between basic research and clinical application, such as drug
development, biomarker assay, and so on, paving a new way to translational medicine.
The high incidence of cardiovascular and cerebrovascular diseases as well as tumors
brought a huge burden to many families and the society. The pathology of these diseases
involves both genetic and environmental risk factors, while the traditional methods are
unable to meet the needs of prevention, diagnosis, treatments, and prognosis assessment
† Professor Lemin Zheng the Editor- of these diseases. The development of multiomics technology brings new chances to
in-Chief of Global Translational translational medicine. There may be two points that will contribute to the success of
Medicine.
translational medicine, one is using the methods of multiomics to explore new targets
*Corresponding author: and drugs, and the other is optimizing preclinical models.
Lemin Zheng
(zhengl@bjmu.edu.cn) The most downloaded articles in the first two issues of Global Translation Medicine
Citation: Zheng L, 2022, Inaugural are related to genomics, metabolomics, and preclinical animal models in cardiovascular
editorial: A new platform dedicated to disease (CVD) and idiopathic pulmonary fibrosis (IPF).
promote bench-to-bedside translation.
Global Transl Med, 1(2): 315. The first article reviewed the genetic and non-genetic risk factors of IPF. IPF is
[1]
https://doi.org/10.36922/gtm.v1i2.315
the most common form of fibrosis of internal organs. The etiology and pathogenesis
Received: December 27, 2022 of IPF are still not well understood. However, a growing line of evidence shows that
Published Online: December 30,
2022 both genetic and non-genetic factors contribute to IPF development. The release of
pro-inflammatory cytokines activates the immune cells. The enhanced synthesis of
Copyright: © 2022 Author(s).
This is an Open Access article interleukins and cytokines, especially transforming growth factor β1, leads to the
distributed under the terms of the proliferation of fibroblasts, increased extracellular matrix formation, and epithelial-
Creative Commons Attribution mesenchymal transformation of the lung tissue. These pathological changes could
License, permitting distribution,
and reproduction in any medium, lead to fibrosis. Polymorphisms of genes responsible for the function of mucociliary
provided the original work is clearance (MUC5B), telomerases (TERT, TERC), as well as signaling pathway-related
properly cited. genes, such as Sonic hedgehog, Wnt, and some other genes, are also risk factors for IPF
Publisher’s Note: AccScience development. Epigenetic regulatory mechanisms, such as methylation and acetylation of
Publishing remains neutral with DNA and histones, may also influence the development and progression of this disease.
regard to jurisdictional claims in
published maps and institutional At present, the role of non-coding RNAs, particularly long non-coding RNAs (lncRNA)
affiliations. in the development of fibrotic processes, is actively studied. LncRNA is an RNA that

Volume 1 Issue 2 (2022) 1 https://doi.org/10.36922/gtm.v1i2.315