Page 21 - GTM-1-2

Global Translational Medicine

ORIGINAL RESEARCH ARTICLE
Association of insulin-like growth factor-1 and

insulin-like growth factor-binding protein-3 with
estimated glomerular filtration rate in patients

with type 2 diabetes mellitus

Sheng Jiang * and Jing Yang †
†
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases
in Central Asia, Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical
University, Urumqi 830 017, China

Abstract

Type 2 diabetes mellitus patients often suffer from kidney damage, which is more
serious than in ordinary people. The insulin-like growth factor (IGF) system has
synergistic effects with other hormonal axes and has an essential role in glucose
metabolism and type 2 diabetes. The study aimed to observe the association of
IGF-1 and IGF factor-binding protein-3 (IGFBP-3) with estimated glomerular filtration
rate (eGFR) in patients with type 2 diabetes mellitus. We recruited 521 patients with
type 2 diabetes from the Endocrinology Department of the First Affiliated Hospital of
Xinjiang Medical University from March 1, 2021, to December 20, 2021. The clinical
† These authors contributed equally data we collected were analyzed to determine the association of IGF-1 and IGFBP-3
to this work. with eGFR in patients with type 2 diabetes. Spearman correlation analysis showed
*Corresponding author: that eGFR was positively correlated with IGF-1 and IGFBP-3 in all subjects (P = 0.044
Sheng Jiang
(xjyj0611@126.com) and P = 0.004, respectively). We developed a linear regression model. In the multiple
linear regression model, serum IGF-1 and IGFBP-3 were positively correlated with
Citation: Jiang S, Yang J, 2022,
Association of insulin-like growth eGFR (β = 0.03, 95% CI = 0.01 – 0.06; P = 0.009 and β = 1.29, 95% CI = 0.09 – 2.49;
factor-1 and insulin-like growth factor- P = 0.035). The results of the correlations were further validated. This preliminary
binding protein-3 with estimated study demonstrated positive associations of serum IGF-1 and IGFBP-3 levels with
glomerular filtration rate in patients
with type 2 diabetes mellitus. Global eGFR in patients with type 2 diabetes.
Transl Med, 1(2): 62.
https://doi.org/10.36922/gtm.v1i2.62
Keywords: Estimated glomerular filtration rate; Insulin-like growth factor-binding
Received: April 8, 2022
Accepted: August 30, 2022 protein-3; Insulin-like growth factor-1; Kidney function; Type 2 diabetes mellitus
Published Online: September 21,
2022
Copyright: © 2022 Author(s).
This is an Open Access article 1. Introduction
distributed under the terms of the
Creative Commons Attribution Diabetes mellitus, which is a serious global public health problem, is either caused by
License, permitting distribution, impaired insulin secretion or disturbed insulin effect, or usually both . More than 90%
[1]
and reproduction in any medium, of diabetic patients are classified under type 2 diabetes mellitus, which is characterized
provided the original work is
[2]
properly cited. by insulin resistance with or without deficient insulin secretion . It is well known that
diabetes is a risk factor for kidney disease, which can lead to proteinuria, decreased renal
Publisher’s Note: AccScience
Publishing remains neutral with function, and further development of diabetic nephropathy.
regard to jurisdictional claims in
published maps and institutional Approximately half of the patients with type 2 diabetes mellitus will develop chronic
affiliations. kidney disease (CKD) as the disease progresses and manifest increased urinary albumin

Volume 1 Issue 2 (2022) 1 https://doi.org/10.36922/gtm.v1i2.62