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Global Translational Medicine IGF-1 and IGFBP-3 levels are correlated with eGFR

Figure 2. Correlation map reporting Spearman’s correlation values for each comparison.
The bar on the right of the map indicates the color legend of the Spearman’s correlation values calculated for each couple of samples in the matrix. *P < 0.05,
**P < 0.01, ***P < 0.001.

Table 5. Multiple linear regression analysis of the correlation between eGFR and various parameters in patients with type 2
diabetes mellitus
Factors included Model I Model II
β (95% CI) P β (95% CI) P
Diabetes duration (years) −0.15 (−0.35, −0.04) 0.128 −0.15 (−0.35, 0.05) 0.137
SBP (mmHg) −0.25 (−0.35, −0.04) <0.001 −0.25 (−0.36, −0.14) <0.001
DBP (mmHg) 0.25 (0.08, 0.42) 0.005 0.25 (0.08, 0.43) 0.004
FBG (mmol/L) 1.01 (0.48, 1.55) <0.001 0.98 (0.44, 1.52) <0.001
BUN (mmol/L) −4.37 (−5.12, −3.63) <0.001 −4.29 (−5.03, −3.54) <0.001
ALT (U/L) 0.23 (0.11, 0.35) <0.001 0.23 (0.10, 0.35) <0.001
AST (U/L) −0.43 (−0.64, −0.21) <0.001 −0.43(−0.64, −0.22) <0.001
UAER (μg/min) −0.02 (−0.03, −0.01) <0.001 −0.02 (−0.03, −0.01) <0.001
IGF-1 (ng/mL) 0.03 (0.01, 0.06) 0.009 - -
IGFBP-3 (μg/mL] - - 1.29 (0.09, 2.49) 0.035
Β: Regression coefficient, CI: Confidence interval, SBP: Systolic blood pressure, DBP: Diastolic blood pressure, BUN: Blood urea nitrogen, TC: Total
cholesterol, LDL-c: Low-density lipoprotein, HbA1c: Glycated hemoglobin, FPG: Fasting plasma glucose, ALT: Alanine aminotransferase, AST: Aspartate
aminotransferase, UAER: Urinary albumin excretion rate, IGF-1: Insulin-like growth factor-1, IGFBP-3: Insulin-like growth factor-binding protein-3

Volume 1 Issue 2 (2022) 6 https://doi.org/10.36922/gtm.v1i2.62