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Global Translational Medicine IGF-1 and IGFBP-3 levels are correlated with eGFR

Table 3. Spearman’s correlation analysis among IGF‑1and Table 4. Univariate linear regression analysis of the
IGFBP‑3 with other parameters correlation between eGFR and various parameters in
patients with type 2 diabetes mellitus
Variable IGF‑1 IGFBP‑3
Age (years) −0.258 (<0.001) −0.401 (<0.001) Characteristic β 95% CI P
Duration of diabetes (years) 0.007 (0.882) −0.019 (0.657) Age (years) −1.06 −1.17, −0.94 <0.001
SBP (mmHg) −0.013 (0.764) −0.011 (0.792) Diabetes duration (years) −0.46 −0.71, −0.21 <0.001
DBP (mmHg) 0.068 (0.119) 0.093 (0.033) SBP (mmHg) −0.21 −0.32, −0.11 <0.001
Height (cm) 0.104 (0.017) 0.046 (0.291) DBP (mmHg) −0.16 0.00, 0.32 0.057
Weight (kg) 0.027 (0.533) 0.047 (0.275) Height (cm) 0.49 0.27, 0.70 <0.001
BMI (kg/m ) −0.055 (0.204) 0.002 (0.957) Weight (kg) 0.18 0.04, 0.32 0.013
2
2
Glucose metabolism BMI (kg/m ) 0.03 −0.37, 0.42 0.892
FBG (mmol/L) 0.000 (0.992) 0.061 (0.163) IGF-1 (ng/mL) 0.03 0.01, 0.06 0.044
2H-OGTT (mmol/L) −0.021 (0.631) −0.005 (0.916) IGFBP-3 (μg/mL) 2.18 0.71, 3.66 0.004
HbA1c (%) 0.015 (0.719) 0.055 (0.206) FPG (mmol/L) 1.05 0.37, 1.72 0.002
Kidney function 2H-OGTT (mmol/L) 0.38 −0.02, 0.78 0.063
eGFR (ml/min/1.73 m2) 0.088 (0.044) 0.126 (0.004) HbA1c (%) 1.47 0.66, 2.28 <0.001
Cr (μmol/L] 0.056 (0.204) 0.002 (0.968) Cr (μmol/L) −0.61 −0.66, −0.56 <0.001
BUN (mmol/L) 0.072 (0.101) −0.019 (0.665) BUN (mmol/L) −5.32 −6.04, −4.60 <0.001
Liver function ALT (U/L) 0.04 −0.02, 0.09 0.222
ALT (U/L) −0.076 (0.082) −0.026 (0.558) AST (U/L) −0.01 −0.11, 0.09 0.816
AST (U/L) −0.123 (0.005) −0.081 (0.062) TG (mmol/L) 0.73 −0.19, 1.65 0.122
Blood lipids TC (mmol/L) 1.26 −0.24, 2.76 0.099
TG (mmol/L) 0.022 (0.615) 0.261 (0.001) LDL-c (mmol/L) 1.16 −0.74, 3.06 0.231
TC (mmol/L) 0.068 (0.122) 0.311 (<0.001) HDL-c (mmol/L) 0.09 −6.73, 6.91 0.979
LDL-c (mmol/L) 0.057 (0.191) 0.238 (<0.001) 24H-UP (g/24 h) −6.68 −8.43, −4.94 <0.001
HDL-c (mmol/L) 0.064 (0.436) 0.081 (0.301) 24H-UM (mg/24 h) −0.03 −0.03, −0.02 <0.001
Urine protein UAER (μg/min) −0.04 −0.05, −0.02 <0.001
24H-UP (g/24 h) 0.004 (0.926) −0.019 (0.775) Abbreviations: β: Regression coefficient, CI: Confidence interval, SBP:
Systolic blood pressure, DBP: Diastolic blood pressure, BMI: Body
24H-UM (mg/24 h) 0.016 (0.709) 0.013 (0.775)
mass index, IGF-1: Insulin-like growth factor 1, IGFBP-3: Insulin-like
UAER (μg/min) 0.016 (0.709) 0.013 (0.775) growth factor-binding protein 3, FPG: Fasting plasma glucose,
IGFs 2H-OGTT: 2h-oral glucose tolerance test, HbA1c: Glycated
hemoglobin, eGFR: estimated glomerular filtration rate, Cr: Creatinine,
IGF-1 (ng/mL) - 0.550 (<0.001) BUN: Blood urea nitrogen, ALT: Alanine aminotransferase, AST:
IGFBP-3 (μg/mL) 0.550 (<0.001) - Aspartate aminotransferase, TC: Total cholesterol, TG: Triglyceride,
LDL-c: Low-density lipoprotein cholesterol, HDL-c: High-density
Data are given as r (P), r: Spearman’s correlation coefficient. Statistical lipoprotein cholesterol, 24H-UP: 24-h urinary protein, 24H-UM: 24-h
correlation is significant at P<0.05. Abbreviations: SBP: Systolic blood urinary microalbumin, UAER: Urinary albumin excretion rate
pressure, DBP: Diastolic blood pressure, BMI: Body mass index, FPG:
Fasting plasma glucose, 2H-OGTT: 2h-oral glucose tolerance test,
HbA1c: Glycated hemoglobin, eGFR: estimated glomerular filtration IGF-1, IGFBP-3 (β = 1.29, 95% CI = 0.09 – 2.49) remained
rate, Cr: Creatinine, BUN: Blood urea nitrogen, ALT: Alanine positively correlated with eGFR. In multiple linear
aminotransferase, AST: Aspartate aminotransferase, TG: Triglyceride,
TC: Total cholesterol, LDL-c: Low-density lipoprotein cholesterol, regression models, diabetes duration was not associated
HDL-c: High-density lipoprotein cholesterol, 24H-UP: 24-h urinary with eGFR. SBP and BUN were negatively correlated with
protein, 24H-UM: 24-h urinary microalbumin, UAER: Urinary eGFR, while DBP and FBG were positively correlated with
albumin excretion rate, IGF-1: Insulin-like growth factor 1,
IGFBP-3: Insulin-like growth factor-binding protein 3. eGFR (Table 5).
4. Discussion
with eGFR. In Model II, there was no difference in the
correlation between each independent variable and eGFR The patients with type 2 diabetes mellitus are a high-
despite the replacement with IGFBP-3. After adjusting for risk group of renal insufficiency. It is crucial for

Volume 1 Issue 2 (2022) 5 https://doi.org/10.36922/gtm.v1i2.62