Page 73 - GTM-1-2
P. 73
Global T
Global Translational Medicineranslational Medicine Risk factors of idiopathic pulmonary fibrosis
Risk factors of idiopathic pulmonary fibrosis
disease. Am J Respir Cell Mol Biol, 52: 1-13. Hypermethylation-mediated silencing of p14(ARF) in
fibroblasts from idiopathic pulmonary fibrosis. Am J Physiol
https://doi.org/10.1165/rcmb.2014-0132TR
Lung Cell Mol Physiol, 303: L295–L303.
13. Yang IV, Pedersen BS, Rabinovich E, et al., 2014, Relationship
of DNA methylation and gene expression in idiopathic https://doi.org/10.1152/ajplung.00332.2011
pulmonary fibrosis. Am J Respir Crit Care Med, 190: 23. Zhou J, Yi Z, Fu Q, 2019, Dynamic decreased expression
1263–1272. and hypermethylation of secreted frizzled-related protein 1
and 4 over the course of pulmonary fibrosis in mice. Life Sci,
https://doi.org/10.1164/rccm.201408-1452OC
218: 241–252.
14. Bechtel W, McGoohan S, Zeisberg EM, et al., 2010,
Methylation determines fibroblast activation and https://doi.org/10.1016/j.lfs.2018.12.041
fibrogenesis in the kidney. Nat Med, 16: 544–550. 24. Elkouris M, Kontaki H, Stavropoulos A, et al., 2016, SET9-
mediated regulation of TGF-β signaling links protein
https://doi.org/10.1038/nm.2135
methylation to pulmonary fibrosis. Cell Rep, 15: 2733–2744.
15. Xu X, Tan X, Tampe B, et al., 2015, Epigenetic
balance of aberrant Rasal1 promoter methylation and https://doi.org/10.1016/j.celrep.2016.05.051
hydroxymethylation regulates cardiac fibrosis. Cardiovasc 25. Jiang Y, Xiang C, Zhong F, et al., 2021, Histone H3K27
Res, 105: 279–291. methyltransferase EZH2 and demethylase JMJD3 regulate
hepatic stellate cells activation and liver fibrosis. Theranostics,
https://doi.org/10.1093/cvr/cvv015
11: 361–378.
16. Pastore F, Bhagwat N, Pastore A, et al., 2020, PRMT5
inhibition modulates E2F1 methylation and gene-regulatory https://doi.org/10.7150/thno.46360
networks leading to therapeutic efficacy in JAK2V617F- 26. Irifuku T, Doi S, Sasaki K, et al., 2016, Inhibition of H3K9
mutant MPN. Cancer Discov, 10: 1742–1757. histone methyltransferase G9a attenuates renal fibrosis and
retains klotho expression. Kidney Int, 89: 147–157.
https://doi.org/10.1158/2159-8290.CD-20-0026
https://doi.org/10.1038/ki.2015.291
17. Coward WR, Brand OJ, Pasini A, et al., 2018, Interplay
between EZH2 and G9a regulates CXCL10 gene repression 27. Müller D, Győrffy B, 2022, DNA methylation-based
in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol, diagnostic, prognostic, and predictive biomarkers in
58: 449–460. colorectal cancer. Biochim Biophys Acta Rev Cancer,
1877: 188722.
https://doi.org/10.1165/rcmb.2017-0286OC
https://doi.org/10.1016/j.bbcan.2022.188722
18. Wang Y, Zhang L, Huang T, et al., 2022, The methyl-
CpG-binding domain 2 facilitates pulmonary fibrosis by 28. Zhang X, Liu H, Zhou JQ, et al., 2022, Modulation of
orchestrating fibroblast to myofibroblast differentiation. Eur H4K16Ac levels reduces pro-fibrotic gene expression
Respir J, 27: 2003697. and mitigates lung fibrosis in aged mice. Theranostics, 12:
530–541.
https://doi.org/10.1183/13993003.03697-2020
https://doi.org/10.7150/thno.62760
19. Yang IV, Pedersen BS, Rabinovich E, et al., 2014, Relationship
of DNA methylation and gene expression in idiopathic 29. Schuetze KB, McKinsey TA, Long CS, 2014, Targeting
pulmonary fibrosis. Am J Respir Crit Care Med, 190: cardiac fibroblasts to treat fibrosis of the heart: Focus on
1263–1272. HDACs. J Mol Cell Cardiol, 70: 100–107.
https://doi.org/10.1164/rccm.201408-1452OC https://doi.org/10.1016/j.yjmcc.2014.02.015
20. Sanders YY, Pardo A, Selman M, et al., 2008, Thy-1 30. Li M, Zheng Y, Yuan H, et al., 2017, Effects of dynamic
promoter hypermethylation: A novel epigenetic pathogenic changes in histone acetylation and deacetylase activity on
mechanism in pulmonary fibrosis. Am J Respir Cell Mol Biol, pulmonary fibrosis. Int Immunopharmacol, 52: 272–280.
39: 610–618.
https://doi.org/10.1016/j.intimp.2017.09.020
https://doi.org/10.1165/rcmb.2007-0322OC
31. Zheng Q, Lei Y, Hui S, et al., 2022, HDAC3 promotes
21. Sun L, Xu A, Li M, et al., 2021, Effect of methylation status pulmonary fibrosis by activating NOTCH1 and STAT1
of lncRNA-MALAT1 and MicroRNA-146a on pulmonary signaling and up-regulating inflammasome components
function and expression level of COX2 in patients with AIM2 and ASC. Cytokine, 153: 155842.
chronic obstructive pulmonary disease. Front Cell Dev Biol, https://doi.org/10.1016/j.cyto.2022.155842
9: 667624.
32. Saito S, Zhuang Y, Suzuki T, et al., 2019, HDAC8 inhibition
https://doi.org/10.3389/fcell.2021.667624
ameliorates pulmonary fibrosis. Am J Physiol Lung Cell Mol
22. Cisneros J, Hagood J, Checa M, et al., 2012, Physiol, 316: L175–L186.
Volume 1 Issue 2 (2022) 9 https://doi.org/10.36922/gtm.v1i2.107

