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Global Translational Medicine Telomere length, mtDNA copy number and colorectal cancer

and thus have limited generalizability and may not be Author contributions
applicable to another populations. The geographical
and ethnic variations as well as the difference in CRC Conceptualization: Sofia Malyutina, Vladimir Maximov,
Olga Chervova
rate, related risk factors, and lifestyle profile between Formal analysis: Sofia Malyutina, Olga Chervova, Vitaly
populations might contribute to the population-specific Voloshin
predictive role of studied molecular markers for CRC risk. Investigation: Vladimir Maximov, Pavel Orlov, Andrew
Aside from limitations, this study has its strengths. Ryabikov, Tatiana Nikitenko
For the first time, this prospective case–control study Methodology: Sofia Malyutina, Vladimir Maximov, Olga
investigated the links between LTL and mtDNA-CN as Chervova, Andrew Ryabikov, Mikhail Voevoda,
well as the risk of incident CRC in the Russian population Tatiana Nikitenko
and altogether the Eastern European population. Validation: Sofia Malyutina, Vladimir Maximov, Olga
Chervova, Andrew Ryabikov, Mikhail Voevoda,
It is noteworthy that we used two molecular markers Tatiana Nikitenko
with established association with mortality and several age- Writing – original draft: Sofia Malyutina, Olga Chervova
related diseases [9,14,15,18,52] . We showed a close correlation Writing – review & editing: Sofia Malyutina, Vladimir
between these markers themselves and with age. Maximov, Olga Chervova, Pavel Orlov, Vitaly
Finally, our findings from a Russian cohort offer the Voloshin, Andrew Ryabikov, Mikhail Voevoda,
first evidence of the value of the association of LTL and Tatiana Nikitenko
mtDNA-CN with CRC in the studied population. Our All authors have contributed substantially to this work
findings may be useful for further integration with data and consented to submit the paper to Global Translational
from different populations for large-sample integrative Medicine, and to the best of the authors’ knowledge, the
analysis of the association of LTL and mtDNA-CN with entire research and paper writing process were carried out
CRC. in adherence to the highest academic conduct standards
and publishing ethics code.
6. Conclusion
Ethics approval and consent to participate
In our nested case–control study, LTL and mtDNA-CN
were independent inverse predictors of the 15-year risk The study was conducted according to the guidelines of
of CRC in the middle-aged and elderly (Caucasoid) the Declaration of Helsinki and approved by the Ethics
population cohort in Novosibirsk, West Siberia. These Committee of IIPM – Branch of IC&G SB RAS (Institute of
molecular markers may become useful predictors for Internal and Preventive Medicine – Branch of Federal State
CRC risk and may have potential implications in cancer Budgeted Research Institution, “Federal Research Center,
prevention. At the same time, our findings highlight the Institute of Cytology and Genetics, Siberian Branch of the
relevance for further research to uncover the mechanisms Russian Academy of Sciences”), Protocol #1 from March
behind the association of LTL and mtDNA-CN with 14, 2002 and Protocol #12 from December 8, 2020. The
human health. study was observational and did not involve experiments
on humans, animals, or cell lines. Informed consent was
Acknowledgments obtained from all subjects involved in the study.

We acknowledge the HAPIEE study for baseline data access Consent for publication
and cooperation (Welcome Trust, WT064947, WT081081,
and the US National Institute of Aging 1RO1AG23522). Informed consent was obtained from all subjects (for study
Olga Chervova was supported by grants from The Frances participation, anonymized data analysis and publication).
and Augustus Newman Foundation (172074) and by the Availability of data
EU-H2020 Project “CETOCOEN Excellence” (857560).
The data presented in this study are available in tabulated
Funding form on request. The data are not publicly available due to
ethical restrictions and project regulations.
This study was supported by the RSF grant (No20-15-
00371). References

Conflict of interest 1. United Nations, Department of Economic and Social
Affairs, Population Division, 2017, World Population
The authors declare no conflict of interest. Prospects: The 2017 Revision, Key Findings and Advance

Volume 2 Issue 1 (2023) 10 https://doi.org/10.36922/gtm.v2i1.184