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Global Translational Medicine Use of cardio biomarker in diagnosis of AMI

Figure 3. Biosensor for diagnosing acute myocardial infarction.

including cTnl, and activated by an integrated optical enable the rapid identification and early detection of AMI,
waveguide made of silicon oxynitride. resulting in better patient outcomes and immediate medical
In a multianalyte platform like this, many biomarkers intervention. Myoglobin, cardiac troponins, and CK are
are simultaneously detected, and due to their high examples of cardiac biomarkers that are frequently used
sensitivity, this sort of biochip can act as a POC apparatus. to identify AMI. Biosensors based on principles such as
Markers that can be detected in ELISA-based assays fluorescence, auditory, and colorimetry have also been found
such as cTnl may be detected using a colorimetric and to be promising diagnostic methods for AMI. AMI diagnosis
fluorescent immunoassay. These assays are quick and have has also been proven to be more sensitive and specific when
great sensitivity, but the procedures involved are time- biomarkers linked to oxidative stress and inflammation,
consuming and laborious (Figure 3) [63-66] . such as MMPs and MPO, are used. Further, development of
cardiac biomarkers and biosensors might generate even more
6. Conclusions precise and effective AMI detection methods in the future.
The utility of cardiac biomarkers and biosensors in AMI Acknowledgments
diagnosis cannot be overstated. The high specificity and
sensitivity of cardiac troponin, connected with advances None.
in biosensor technology, have significantly improved
diagnostic accuracy. Biosensors, such as electrochemical Funding
and optical biosensors, offer rapid and precise detection of None.
cardiac biomarkers, enabling timely intervention of diseases.
Conflict of interest
Diagnosis of AMI is therefore dependent on the use
of cardiac biomarkers and biosensors. These techniques The authors declare no conflicts of interest.

Volume 2 Issue 2 (2023) 8 https://doi.org/10.36922/gtm.0403