Page 94 - GTM-2-3

Global Translational Medicine

ORIGINAL RESEARCH ARTICLE
Immediate onset signatures of autoimmune

diseases after vaccination

Darrell O. Ricke*
Department of Research, Molecular BioInsights, Winchester, MA, 01890, USA

Abstract

Severe adverse events, including autoimmune diseases, have been noted in some
individuals following vaccination. It is still unknown whether a subset of these
autoimmune disease adverse events (ADAE) is triggered by the immunization and
is not background chance occurrences. Only a small fraction of adverse events
experienced by vaccinees has been reported to the Vaccine Adverse Event Reporting
System (VAERS) database. In this study, ADAEs within VAERS are examined. The
frequency of autoimmune disease adverse reactions reported immediately following
vaccination was compared to the background population adverse event frequency.
The frequency of immediate-onset autoimmune diseases, extracted from VAERS,
arisen after vaccination was found to exceed the expected background occurrences.
Vaccinees who receive a second COVID-19 mRNA vaccination dose 3 weeks after the
first dose appear to experience an increased number of ADAE. Furthermore, human
papillomavirus (HPV), hepatitis A, and hepatitis B vaccines exhibit distinctive patterns
of associations with autoimmune diseases. The potential role of vaccine aluminum
adjuvant, included in these vaccines, cannot be ruled out as contributing to ADAE.
*Corresponding author: VAERS data illustrate immediate onset correlations for multiple autoimmune
Darrell O. Ricke diseases across various vaccines. Autoimmune diseases immediate temporal onset
(doricke@molecularbioinsights.
com) associations that occur following COVID-19 mRNA and adenoviral vaccinations are
predicted to occur with similar frequencies for all mRNA and adenoviral vaccines and
Citation: Ricke DO, 2023,
Immediate onset signatures therapeutics. Taken together, removal of aluminum adjuvants from HPV, hepatitis A,
of autoimmune diseases after and hepatitis B vaccines, among others, should be considered in the effort to reduce
vaccination. Global Transl Med, the occurrence of immediate-onset autoimmune diseases.
2(3): 1455.
https://doi.org/10.36922/gtm.1455
Received: August 8, 2023 Keywords: Autoimmune diseases; Vaccines; COVID-19 vaccines; Human papillomavirus
Accepted: September 20, 2023 vaccines; Hepatitis vaccines; Aluminum adjuvant
Published Online: September 29,
2023
Copyright: © 2023 Author(s).
This is an Open-Access article 1. Introduction
distributed under the terms of the
Creative Commons Attribution Adverse events following immunization (AEFI) occur with many vaccines. These events
License, permitting distribution,
and reproduction in any medium, encompass adverse events caused by immunization as well as unrelated background
provided the original work is occurrences. The likelihood of reporting them as AEFI decreases as the time between
properly cited. immunization and the onset of autoimmune disease increases, creating a time bias in
Publisher’s Note: AccScience reporting, with a decreasing pattern over time. Following immunization, autoimmune
Publishing remains neutral with diseases occur at background population frequencies unrelated to the immunization
regard to jurisdictional claims in
published maps and institutional itself. The number of background AEFIs should ideally be proportional to autoimmune
affiliations. disease population frequencies for each vaccine dose administered to vaccinees. This

Volume 2 Issue 3 (2023) 1 https://doi.org/10.36922/gtm.1455