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Global Translational Medicine The research advances in HPV integration

87: 1022–1033. https://doi.org/10.1002/ijc.27433.
https://doi.org/10.1002/jmv.24129 43. Adey A, Burton JN, Kitzman JO, et al., 2013, The haplotype-
resolved genome and epigenome of the aneuploid HeLa
33. Reuschenbach M, Huebbers CU, Prigge ES, et al., 2015, cancer cell line. Nature, 500: 207–211.
Methylation status of HPV16 E2-binding sites classifies
subtypes of HPV-associated oropharyngeal cancers. Cancer, https://doi.org/10.1038/nature12064
121: 1966–1976. 44. Shen C, Liu Y, Shi S, et al., 2017, Long-distance interaction of
https://doi.org/10.1002/cncr.29315 the integrated HPV fragment with MYC gene and 8q24.22
region upregulating the allele-specific MYC expression in
34. Ehrig F, Hafner N, Driesch C, et al., 2019, Differences in HeLa cells. Int J Cancer, 141: 540–548.
stability of viral and viral-cellular fusion transcripts in HPV-
induced cervical cancers. Int J Mol Sci, 21: 112. https://doi.org/10.1002/ijc.30763
https://doi.org/10.3390/ijms21010112 45. Mainguene J, Vacher S, Kamal M, et al., 2022, Human
papilloma virus integration sites and genomic signatures
35. Jeon S, Lambert PF, 1995, Integration of human in head and neck squamous cell carcinoma. Mol Oncol,
papillomavirus type 16 DNA into the human genome leads 16: 3001–3016.
to increased stability of E6 and E7 mRNAs: implications
for cervical carcinogenesis. Proc Natl Acad Sci U S A, 92: https://doi.org/10.1002/1878-0261.13219
1654–1658. 46. Zapatka M, Borozan I, Brewer DS, et al., 2020, The landscape
https://doi.org/10.1073/pnas.92.5.1654 of viral associations in human cancers. Nat Genet, 52:
320–330.
36. Jeon S, Allen-Hoffmann BL, Lambert PF, 1995, Integration
of human papillomavirus type 16 into the human genome https://doi.org/10.1038/s41588-019-0558-9
correlates with a selective growth advantage of cells. J Virol, 47. Li W, Tian S, Wang P, et al., 2019, The characteristics of
69: 2989–2997. HPV integration in cervical intraepithelial cells. J Cancer,
https://doi.org/10.1128/JVI.69.5.2989-2997.1995 10: 2783–2787.
37. Zhi W, Wei Y, Lazare C, et al., 2022, HPV-CCDC106 https://doi.org/10.7150/jca.31450
integration promotes cervical cancer progression by 48. Warburton A, Markowitz TE, Katz JP, et al., 2021,
facilitating the high expression of CCDC106 after HPV E6 Recurrent integration of human papillomavirus genomes at
splicing. J Med Virol, 95: e28009. transcriptional regulatory hubs. NPJ Genom Med, 6: 101.
https://doi.org/10.1002/jmv.28009 https://doi.org/10.1038/s41525-021-00264-y
38. Steenbergen RDM, Snijders PJF, Heideman DAM, et al., 49. Chaiwongkot A, Vinokurova S, Pientong C, et al., 2013,
2014, Clinical implications of (epi)genetic changes in HPV- Differential methylation of E2 binding sites in episomal and
induced cervical precancerous lesions. Nat Rev Cancer, integrated HPV 16 genomes in preinvasive and invasive
14: 395–405. cervical lesions. Int J Cancer, 132: 2087–2094.
https://doi.org/10.1038/nrc3728 https://doi.org/10.1002/ijc.27906
39. Hafner N, Driesch C, Gajda M, et al., 2008, Integration of 50. Johannsen E, Lambert PF, 2013, Epigenetics of human
the HPV16 genome does not invariably result in high levels papillomaviruses. Virology, 445: 205–212.
of viral oncogene transcripts. Oncogene, 27: 1610–1617.
https://doi.org/10.1016/j.virol.2013.07.016
https://doi.org/10.1038/sj.onc.1210791
51. Bryant D, Onions T, Raybould R, et al., 2014, Increased
40. Kraus I, Driesch C, Vinokurova S, et al., 2008, The majority methylation of human papillomavirus type 16 DNA
of viral-cellular fusion transcripts in cervical carcinomas correlates with viral integration in Vulval intraepithelial
cotranscribe cellular sequences of known or predicted neoplasia. J Clin Virol, 61: 393–399.
genes. Cancer Res, 68: 2514–2522.
https://doi.org/10.1016/j.jcv.2014.08.006
https://doi.org/10.1158/0008-5472.CAN-07-2776
52. Hatano T, Sano D, Takahashi H, et al., 2017, Identification
41. Bodelon C, Untereiner ME, Machiela MJ, et al., 2016, of human papillomavirus (HPV) 16 DNA integration and
Genomic characterization of viral integration sites in HPV- the ensuing patterns of methylation in HPV-associated head
related cancers. Int J Cancer, 139: 2001–2011. and neck squamous cell carcinoma cell lines. Int J Cancer,
140: 1571–1580.
https://doi.org/10.1002/ijc.30243
https://doi.org/10.1002/ijc.30589
42. Schmitz M, Driesch C, Beer-Grondke K, et al., 2012, Loss
of gene function as a consequence of human papillomavirus 53. Dooley KE, Warburton A, McBride AA, 2016, Tandemly
DNA integration. Int J Cancer, 131: E593–E602. integrated HPV16 can form a brd4-dependent super-

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