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Global Translational Medicine Immune response in humans due to COVID-19 infection

pH. This mechanism renders the Omicron endosomal Consent for publication
entry route temperature-sensitive, enabling more
effective operation in the upper respiratory tract than Not applicable.
the lung parenchyma, in contrast to the temperature- Availability of data
insensitive TMPRSS2 pathway. As Omicron infection
63
predominantly affects the upper respiratory tract, it Not applicable.
reduces the pathogenicity of SARS-CoV-2 at this stage
of the pandemic by limiting viral dissemination to other References
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Acknowledgments doi: 10.1038/s41401-020-0485-4
None. 7. Williams H, Hutchinson D, Stone H. Watching brief: The
evolution and impact of COVID-19 variants B.1.1.7, B.1.351,
Funding P.1 and B.1.617. Glob Biosecur. 2021;3(1).
doi: 10.31646/gbio.112
None.
8. Huang C, Wang Y, Li X, et al. Clinical features of patients
Conflict of interest infected with 2019 novel coronavirus in Wuhan, China.
Lancet. 2020;395(10223):497-506.
The authors declare no conflicts of interest.
doi: 10.1016/S0140-6736(20)30183-5
Author contributions 9. Acharya D, Liu G, Gack MU. Dysregulation of type I
Conceptualization: Chayan Munshi interferon responses in COVID-19. Nat Rev Immunol.
Writing – original draft: Mihieka Bose 2020;20(7):397-398.
Writing – review & editing: All authors doi: 10.1038/s41577-020-0346-x

Ethics approval and consent to participate 10. Hsu JCC, Laurent-Rolle M, Pawlak JB, Wilen CB, Cresswell P.
Translational shutdown and evasion of the innate immune
Not applicable. response by SARS-CoV-2 NSP14 protein. Proc Natl Acad Sci

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