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Global Translational Medicine

REVIEW ARTICLE
The dawn of personalized multi-omics:

Detecting disease before you know it

Filip Mundt Madsen *
1,2
1 Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark
2 Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences,
University of Copenhagen, Copenhagen, Denmark

Abstract

Recent advancements in omics techniques have enabled deep profiling of an
individual’s molecular makeup. The wealth of data produced offers insights into
genetic predispositions, early disease markers, and personalized treatment strategies.
However, the full potential of omics data emerges when combined into longitudinal
and personal multi-omics space. Another interesting venue is the inclusion of
continuous monitoring of physiological parameters through wearable technology.
Wearable health devices, including smartwatches and biosensors, provide real-
time data on heart rate, oxygen saturation, sleep patterns, activity levels, and much
more. By integrating with omics data, wearables offer a comprehensive view of an
individual’s health, allowing for early detection of deviations from normalcy. This
convergence allows for the prediction and prevention of diseases at the individual
level and provides a powerful monitoring tool in clinical and drug developmental
settings. This review explores the fusion of omics and wearable technology,
envisioning their synergy as a catalyst for a transformative shift in modern healthcare.
Their merging enables predictive and personalized medicine. As these technologies
continue to evolve, their translation into routine clinical practice holds the promise of
*Corresponding author: a healthier future for all. Provided herein is a step-by-step vision for how longitudinal
Filip Mundt Madsen
(FPMN@novonordisk.com) personalized multi-omics, combined with wearable devices, will guide proactive
healthcare and transform drug discovery in translational medicine.
Citation: Madsen FM. The dawn of
personalized multi-omics: Detecting
disease before you know it. Global Keywords: Genomics; Proteomics; Metabolomics; Multi-omics; Wearable health
Transl Med. 2024;3(1):2357.
https://doi.org/10.36922/gtm.2357 technology; Precision medicine; Personalized medicine; Translational medicine
Received: December 2, 2023
Accepted: January 31, 2024
Published Online: March 25, 2024
Copyright: © 2024 Author(s). 1. Introduction
This is an Open Access article Precision medicine, a medical field that encompasses personalized medicine, is gaining
distributed under the terms of the
Creative Commons Attribution substantial attention today. It aims to provide tailored health-care solutions based on an
License, permitting distribution, individual’s unique molecular makeup, lifestyle, and environment. Since its inception,
and reproduction in any medium, the approach has been revolutionizing medical research, leading to more effective
provided the original work is
properly cited. treatments, drug discovery, and better health outcomes for patients.
Publisher’s Note: AccScience In this paper, the potential for how personalized multi-omics and wearable health
Publishing remains neutral with technologies could further develop precision medicine is reviewed. Omics and multi-
regard to jurisdictional claims in
published maps and institutional omics are first introduced, followed by a section regarding wearable health trackers.
affiliations. A vision will be presented on how the integration of these two technologies could lead

Volume 3 Issue 1 (2024) 1 https://doi.org/10.36922/gtm.2357