Page 122 - GTM-3-4

Global Translational Medicine Sleep apnea in patients with tachyarrhythmias

that the STOP-BANG Questionnaire was ineffective as a 5. Conclusion
screening tool for moderate to severe OSA (AUC 0.654,
95% CI 0.580–0.728). 27 The prevalence of OSA among patients with AF and
atrial flutter is quite high, which considerably affects their
In a meta-analysis by Ramachandran and Josephs a course. However, the current diagnostic capabilities of
comparison of the accuracy of various predictive models OSA are limited because of the small number of hospitals
and questionnaires for sleep apnea using diagnostic OR where it can be primarily diagnosed. Screening methods
demonstrated that the Berlin Questionnaire (OR 2.28 such as the STOP-BANG Sleep Apnea Risk Scale and
[95% CI: 7.46 – 69.66]) exhibited a better predictive value Berlin Questionnaire demonstrated high sensitivity. Thus,
for severe OSA than the other questionnaires (STOP- all patients with AF and flutter can be screened using
28
BANG OR 6.59 [95% CI: 3.22 – 13.49]). The meta- these questionnaires. The study of additional screening
analysis included studies with patients with CVS who were tools or the combination of questionnaires with objective
undergoing orthopedic surgeries. measurements (polysomnography) in clinical settings may
Delesie et al. found that in patients with AF, the validate our findings.
sensitivity and specificity of the Epworth Sleepiness Scale
(score > 11), Berlin Questionnaire (high risk), and STOP- Acknowledgment
BANG Sleep Apnea Risk Scale (high risk) were 30.4% and None.
74.2%, 50.7% and 80.6%, 59.4% and 61.3%, respectively.
29
Moreover, the AUCs of the Epworth Sleepiness Scale, Funding
Berlin Questionnaire, and STOP-BANG Questionnaire This research was funded by a grant from the Moscow
were 0.532 (0.411 – 0.654; k = 0.034), 0.704 (0.592 – 0.817; k Government for the implementation of a scientific and
= 0.251), and 0.673 (0.553 – 0.794; k = 0.181), respectively.
practical project in medicine No. 0702-2.
Lin et al. also reported similar results after evaluating
the risk factors and STOP-BANG Questionnaire in Conflict of interest
patients with AF. The AUC was 0.705 (95% CI: 0.519 The authors declare that there are no conflicts of interest
30
– 0.892), and the sensitivity and specificity were 94.2% with any financial organization regarding the work
and 45.5%, respectively. Spearman’s correlation analysis discussed in this manuscript.
revealed a strong positive correlation between the STOP-
BANG scores and AHI (r = 0.449; P < 0.0001). Multiple Author contributions
linear regression with AHI as the dependent variable and
the STOP-BANG score as the predictor was also significant Conceptualization: Azamat Maratovich Baymukanov
(t = 4.286; P < 0.0001). Data curation: Irina Andreevna Bulavina, Maria
Vladimirovna Yunayeva
Rogel et al. demonstrated that the standard use of the Formal analysis: Yuliya Dmitrievna Weissman
STOP-BANG questionnaire can contribute to a more Investigation: Irina Andreevna Bulavina, Maria
effective identification and treatment referral of patients Vladimirovna Yunayeva, Yuliya Dmitrievna Weissman
with OSA. 31 Methodology: Azamat Maratovich Baymukanov
The study had the following limitations: Writing-original draft: Yuliya Dmitrievna Weissman
Writing-review & editing: Azamat Maratovich Baymukanov,
(i) This was a single-center study with a small sample size Ilya Leonidovich Ilyich, Sergey Arturovich
(ii) The patients had significant pre-existing comorbid Termosesov, Artem Anatolievich Evmenenko
conditions (e.g., heart failure, diabetes mellitus, and
history of stroke) Ethics approval and consent to participate
(iii) This study included patients referred to the hospital
for pulmonary vein radiofrequency catheter or The study was conducted in accordance with the Helsinki
cryoballoon isolation, cavotricuspid isthmus Declaration and approved by the Ethics Committee
radiofrequency catheter ablation, or electrical of Moscow City Clinical Hospital after V.M. Buyanov
cardioversion (protocol code 115/5 from 9 June 2022).
(iv) All patients underwent RM rather than Consent for publication
polysomnography. Polysomnography was not
performed because of the lack of specialized During patient recruitment, informed consent of patients
equipment. Thus, the authors decided to use RM for was obtained. Any personal information was excluded
primary diagnosis. from the study.

Volume 3 Issue 4 (2024) 6 doi: 10.36922/gtm.5059