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Global Translational Medicine





                                        PERSPECTIVE ARTICLE
                                        Patient-oriented and clinical considerations

                                        supporting the single-incision subepithelial
                                        connective tissue harvest



                                        Han S. Kim 1  , Denise M. Cacho 1  , Alan R. George 1  , Joseph K. Retrum 2  ,
                                        Carsen R. McDaniel 3  , Adam R. Lincicum 1  , Kimberly Ann Inouye 1  ,
                                                                                 1
                                        Brian W. Stancoven 1  , and Thomas M. Johnson *
                                        1 Department of Periodontics,  Army Postgraduate Dental School, Postgraduate Dental College,
                                        Uniformed Services University, Fort Eisenhower, Augusta, Georgia, United States of America
                                        2 Department of Periodontics, United States Army Dental Activity, Fort Riley, Kansas, United States
                                        of America
                                        3 Department of Periodontics,  Army Postgraduate Dental School, Postgraduate Dental College,
                                        Uniformed Services University, Fort Bliss, El Paso, Texas, United States of America
                                        (This article belongs to the Special Issue: Soft and Hard Tissues Reconstruction in Dentistry)




                                        Abstract
                                        The subepithelial connective tissue graft (SCTG) has become the gold standard for
            *Corresponding author:      treating gingival recession. In addition, SCTG is a reliable technique for augmenting
            Thomas M. Johnson
            (thomas.m.johnson34.mil@health.  the dimensions of attached gingiva and peri-implant mucosa, thereby supporting
            mil)                        periodontal and peri-implant health and stability. Various autogenous soft-tissue
            Citation: Kim HS, Cacho DM,   harvesting techniques have been developed for use in periodontal plastic surgery,
            George AR, et al. Patient-oriented   each with its own set of advantages and limitations. Over the past 5 years, updated
            and clinical considerations   reviews of human palatal anatomy have influenced clinical decision-making
            supporting the single-incision
            subepithelial connective tissue   regarding SCTG harvesting, expanding the safety zone for palatal SCTG procedures.
            harvest. Global Transl Med.   New histological and molecular findings have provided insights into the underlying
            2025:4(1):35-46.            mechanisms that may explain the observed differences in clinical outcomes based
            doi: 10.36922/gtm.4860
                                        on the harvesting method and graft type. The purpose of this paper is to recommend
            Received: September 15, 2024  a preferred SCTG harvesting technique applicable to most cases and to identify
            1st revised: November 10, 2024  specific clinical scenarios where available evidence may support the use of alternative
                                        methods.
            2nd revised: November 23, 2024
            Accepted: November 25, 2024
                                        Keywords: Clinical protocols; Esthetics; Palate; Hard; Patient satisfaction; Tissue
            Published online: December 16,   transplantation; Treatment outcome
            2024
            Copyright: © 2024 Author(s).
            This is an Open-Access article
            distributed under the terms of the
            Creative Commons Attribution   1. Introduction
            License, permitting distribution,
            and reproduction in any medium,   Compared to alternative treatment methods, subepithelial connective tissue graft
            provided the original work is   (SCTG)-based procedures are known to achieve complete root coverage most frequently,
            properly cited.             offer the highest average root coverage percentage, and provide the most favorable
                                                                1-3
            Publisher’s Note: AccScience   temporal stability of results.  However, both patients and clinicians must make
            Publishing remains neutral with   concessions to attain this level of clinical predictability. Autologous soft-tissue harvesting
            regard to jurisdictional claims in
            published maps and institutional   has been associated with postoperative complications such as prolonged bleeding,
            affiliations.               neurosensory dysfunction, flap necrosis, and discomfort, particularly when the operator

            Volume 4 Issue 1 (2025)                         35                              doi: 10.36922/gtm.4860
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