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Global Translational Medicine Thyroid status in obesity

contribute to metabolic dysregulation, and insulin Consent for publication
resistance exacerbates thyroid dysfunction.
Not applicable.
From a clinical point of view, these findings underscore
the long-term risk of developing hypothyroidism in obesity. Availability of data
Given the strong link between obesity, insulin resistance, The datasets used and/or analyzed are available from the
and thyroid dysfunction, overweight individuals should Institute of Physiology of the National Academy of Sciences
undergo regular thyroid function assessments, including of Belarus, upon reasonable and justifiable request in
an ultrasound examination of the thyroid gland and accordance with the rules and procedures of the institute
determination of the thyroid hormonal status. (https://physiology.by/or biblio@fizio.bas-net.by).

5. Conclusion References
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decrease in TPO activity. Morphological studies of the doi: 10.1136/bmjgh-2022-009773
thyroid gland further support this emerging hypothyroid 2. Reinehr T. Obesity and thyroid function. Mol Cell Endocrinol.
state, revealing lipid inclusions, enlarged follicles with 2010;316(2):165-171.
colloid accumulation, and flattened thyrocytes in both
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Funding
4. Du FM, Kuang HY, Duan BH, Liu DN, Yu XY. Associations
This work was supported by the State Program for Scientific between thyroid hormones within the euthyroid range and
Research of the National Academy of Sciences of Belarus indices of obesity in obese Chinese women of reproductive
(No.: 4.1.1.5). age. Metab Syndr Relat Disord. 2019;17(8):416-422.
doi: 10.1089/met.2019.0036
Conflict of interest
5. Alevizaki M, Saltiki K, Voidonikola P, Mantzou E,
The authors declare that they have no competing interests. Papamichael C, Stamatelopoulos K. Free thyroxine is an
independent predictor of subcutaneous fat in euthyroid
Author contributions individuals. Eur J Endocrinol. 2009;161(3):459-465.
Conceptualization: Tatyana A. Mityukova doi: 10.1530/EJE-09-0441
Formal analysis: All authors 6. Song RH, Wang B, Yao QM, Li Q, Jia X, Zhang JA. The
Investigation: Anastasia A. Basalai, Tatyana E. Kuznetsova, impact of obesity on thyroid autoimmunity and dysfunction:
Olga Y. Poluliakh, Mikita S. Kastsiuchenka A systematic review and meta-analysis. Front Immunol.
Methodology: Anastasia A. Basalai, Tatyana E. Kuznetsova, 2019;10:2349.
Olga Y. Poluliakh, Mikita S. Kastsiuchenka doi: 10.3389/fimmu.2019.02349
Writing – original draft: Tatyana A. Mityukova, Anastasia 7. Yan Y, Xu M, Wu M, et al. Obesity is associated with
A. Basalai, Tatyana E. Kuznetsova subclinical hypothyroidism in the presence of thyroid
Writing – review & editing: All authors autoantibodies: A cross-sectional study. BMC Endocr

Ethics approval and consent to participate Disord. 2022;22(1):94.
doi: 10.1186/s12902-022-00981-0
This study was approved by the Bioethics Committee of
the Institute of Physiology, National Academy of Sciences 8. Gancheva S, Zhelyazkova-Savova M, Galunska B,
Chervenkov T. Experimental models of metabolic syndrome
of Belarus (Protocols No.1 on January 22, 2021; Protocols in rats. Scr Sci Med. 2015;47(2):14-21.
No.2 on February 2, 2022) and conducted in accordance
with the guidelines set forth by the European Convention doi: 10.14748/ssm.v47i2.1145
for the Protection of Vertebrate Animals (ETS No. 123). 9. Marcondes FK, Bianchi FJ, Tanno AP. Determination of the

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