Page 114 - GTM-4-3

Global Translational Medicine

ORIGINAL RESEARCH ARTICLE
CoreView imaging on needle: Rapid core-needle

biopsy imaging for point-of-care breast cancer
diagnosis

Jocelyn R. Jensen 1,2 , Duy Do 2,3 , Yuan-ping Chang 2 , Sophia Anderson 2,3 ,
Matthew D. Carson 2 , Suzanne Dintzis 4 , Richard M. Levenson 5 , and
Eric J. Seibel 1,2,3 *

1 Department of Bioengineering, College of Engineering and UW Medicine, University of Washington,
Seattle, Washington, United States of America
2 Human Photonics Laboratory, College of Engineering, University of Washington, Seattle,
Washington, United States of America
3 Department of Mechanical Engineering, College of Engineering, University of Washington, Seattle,
Washington, United States of America
4 Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington,
Seattle, Washington, United States of America
5 Department of Pathology and Laboratory Medicine, UC Davis Health, University of California,
Davis, California, United States of America

Abstract

Breast cancer (BC) is one of the most prevalent malignancies worldwide, with early and
*Corresponding author: rapid diagnosis playing a critical role in improving patient outcomes. Core-needle biopsies
Eric J. Seibel
(eseibel@uw.edu) (CNBs) are the current gold standard for minimally invasive BC diagnoses. However, in
low-resource and rural settings, access to CNB diagnostics is limited by infrastructural
Citation: Jensen JR, Do D,
Chang Y, et al. CoreView imaging constraints, long histopathology turnaround times, as well as financial and geographical
on needle: Rapid core-needle barriers. To address these challenges, we developed the CoreView imaging on needle
biopsy imaging for point-of-care (ION), an affordable, integrated imaging system designed to provide rapid, and point-
breast cancer diagnosis. Global of-care diagnostic assessment of CNB samples. The CoreView ION integrates microscopy
Transl Med. 2025;4(3):106-118.
doi: 10.36922/GTM025170039 with ultraviolet surface excitation technology, enabling the imaging of tissue biopsy
surfaces within 5 min, significantly reducing diagnostic delays. This study presents the
Received: April 21, 2025
design, fabrication, and verification of the CoreView ION prototype operation, including
Revised: May 27, 2025 its imaging workflow, staining protocols, and tissue compression testing. Our results
Accepted: August 15, 2025 demonstrate that the system can successfully generate histology-grade images of
porcine and murine fresh biopsies, preserving cellular and nuclear detail of normal and
Published online: September 10,
2025 tumor tissue. By streamlining CNB imaging and incorporating mainly manual low-cost
components, the CoreView ION has the potential to improve BC diagnostics in low-
Copyright: © 2025 Author(s).
This is an Open-Access article resource settings, ultimately enhancing early detection and patient care.
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution, Keywords: Microscopy with ultraviolet surface excitation imaging; Point-of-care; Global
and reproduction in any medium, health; Breast cancer; Diagnostics
provided the original work is
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with 1. Introduction
regard to jurisdictional claims in
published maps and institutional Breast cancer (BC) is characterized by dysregulated cell proliferation within breast
affiliations. epithelium, with common types being invasive ductal or invasive lobular carcinoma.

Volume 4 Issue 3 (2025) 106 doi: 10.36922/GTM025170039