Page 59 - GTM-4-3

Global Translational Medicine

PERSPECTIVE ARTICLE
Perspectives: Recent advances in community-

based interventions for cardiovascular disease
disparities in the United States

Farbod Zahedi Tajrishi 1 , Daphne P. Ferdinand , William Herbst , Linda R.
1
2
Peterson , and Keith C. Ferdinand *
3
1
1 Division of Cardiology, Tulane University School of Medicine, New Orleans, Louisiana, United States
of America
2 Healthy Heart Community Prevention Project, Inc., New Orleans, Louisiana, United States of
America
3 Division of Cardiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri,
United States of America

Abstract
Despite decades of progress in prevention and management, cardiovascular disease
(CVD) remains the leading cause of mortality in the United States (US) and globally,
with persistent and even widening disparities in outcomes across racial, ethnic,
geographic, and socioeconomic groups. As a complement to clinical care, community-
based interventions have emerged as vital tools in promoting cardiovascular health,
*Corresponding author: particularly in underserved populations. This perspective focuses on recent advances
Keith C. Ferdinand
(kferdina@tulane.edu) in US-based community interventions for CVD, while acknowledging global relevance,
and explores the historical evolution, current landscape, and future directions of
Citation: Tajrishi FZ, Ferdinand DP, community-driven CVD prevention strategies. We highlight foundational models
Herbst W, Peterson LR,
Ferdinand KC. Perspectives: such as the Healthy Heart Community Prevention Project in New Orleans, Louisiana,
Recent advances in community- and examine recent major studies and innovations in the field from the US and across
based interventions for the world. Community-rooted programs demonstrate growing potential to address
cardiovascular disease disparities
in the United States. Global Transl upstream determinants of cardiovascular health. Their continued success, however,
Med. 2025;4(3):51-59. will depend on sustained investment, robust evaluation frameworks, and alignment
doi: 10.36922/GTM025170040 with clinical care pathways and health policy infrastructure.
Received: April 24, 2025
Revised: May 28, 2025 Keywords: Community interventions; Cardiovascular disorders; Hypertension; Disparities
Accepted: July 1, 2025
Published online: July 25, 2025
Copyright: © 2025 Author(s). 1. Introduction
This is an Open-Access article
distributed under the terms of the Cardiovascular disease (CVD), including coronary artery disease, myocardial infarction,
Creative Commons Attribution heart failure, cerebrovascular disease, and other related disorders, is the primary cause of
License, permitting distribution,
and reproduction in any medium, morbidity and mortality worldwide, including the United States (US). Despite significant
provided the original work is advancements in prevention and treatment, recent data suggest that CVD rates continue
properly cited. to rise. While age-adjusted mortality rates may have slightly declined, the total number
1,2
Publisher’s Note: AccScience of CVD-related deaths increased by over 10,000 in the US from 2021 to 2022, indicating
Publishing remains neutral with the ongoing need to identify and implement more effective strategies for CVD prevention
regard to jurisdictional claims in 1
published maps and institutional and control. Traditional clinical care, including visits to physicians, nurse practitioners,
affiliations. and other clinicians, remains essential to control cardiometabolic risk factors such

Volume 4 Issue 3 (2025) 51 doi: 10.36922/GTM025170040