Page 365 - IJB-10-1

International

Journal of Bioprinting

RESEARCH ARTICLE
RESEARCH ARTICLE
Improving the transdermal delivery of
vitamin C by 3D-printed microneedle particles
for alleviating skin photodamage

Li Zhang , Haofan Liu , Linghong Guo 2,3,4† , Xuebing Jiang , Siyi Wang ,
1
1,5
1†
1†
Run Tian , Yiting Huang , Xian Jiang *, and Maling Gou *
1,2
2,3
1
1
1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University,
610041 Chengdu, China
2 Department of Dermatology, West China Hospital, Sichuan University, 610041 Chengdu, China
3 Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science
Center for Disease-related Molecular Network, West China Hospital, Sichuan University, 610041
Chengdu, China
4 Tianfu Jincheng Laboratory & Institute of Future Medical Innovation, City of Future Medicine,
641400 Chengdu, China
5 Huahang Microcreate Technology Co., Ltd, 610042 Chengdu, China

Abstract

Skin photodamage is a common disease that can cause various skin problems, and
† These authors contributed equally vitamin C is frequently used as an antioxidant to protect the skin from photodamage.
to this work. However, vitamin C is a charged and hydrophilic molecule, which decreases skin
*Corresponding authors: permeability. In this study, we developed a type of microneedle particles (MNPs)
Maling Gou to enhance topical vitamin C delivery. The MNPs are millimeter-sized particles with
(goumaling@scu.edu.cn) micron-sized needle-like structures that can be rapidly and accurately fabricated
Xian Jiang
(jiangxian@scu.edu.cn) through a digital light processing (DLP)-based micro-printing process. The
mechanical properties of these MNPs are reliable for forming micropores across the
Citation: Zhang L, Liu H, Guo L,
et al. Improving the transdermal stratum corneum in a painless manner. Following a topical application to the dorsal
delivery of vitamin C by 3D-printed skin of mice, the MNPs increased the permeability of medications. The effectiveness
microneedle particles for alleviating of vitamin C in mitigating skin photodamage is significantly improved. In conclusion,
skin photodamage. Int J Bioprint.
2024;10(1):1285. this study presents micro-printing of MNPs for transdermal vitamin C delivery, which
doi: 10.36922/ijb.1285 has potential applications in future treatment of skin photodamage.
Received: July 11, 2023
Accepted: August 15, 2023 Keywords: Microneedle particles; Micro-printing; Vitamin C delivery; Skin
Published Online: January 8, 2024
photodamage
Copyright: © 2024 Author(s).
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution, 1. Introduction
and reproduction in any medium,
provided the original work is Skin is the physical barrier between the human body and the external environment.
properly cited.
It is responsible for many important physiological functions, including perspiration,
Publisher’s Note: AccScience sensation of heat and pain, etc. Physical, mechanical, and chemical factors as well as
Publishing remains neutral with pathogenic microbes can cause skin damage. Ultraviolet (UV)-induced skin damage is
regard to jurisdictional claims in
published maps and institutional one of the most common skin injuries that individuals encounter in their daily lives.
affiliations. Exposure to UV radiation can result in various detrimental effects on the skin, such

Volume 10 Issue 1 (2024) 357 https://doi.org/10.36922/ijb.1285