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International Journal of Bioprinting                                         PEDOT/PSS-based sensors




            of capturing both physiological and biochemical signals.   (4)   Miniaturization and  integration. Advances in
            This is exemplified by sensors that can monitor both    fabrication techniques could lead to smaller, more
            ECG signals and glucose levels in sweat during physical   compact sensors that can be seamlessly integrated
            activities. Such multi-functional biosensors offer a holistic   into a wide range of wearable devices, textiles, and
            perspective, merging real-time physiological responses   even implantable medical devices.
            with biochemical variations.
                                                               (5)   Adaptive  and  self-powered  sensors.  Future
            6. Concluding remarks and prospects                     PEDOT:PSS sensors might harness energy from
                                                                    their surroundings or body movements, allowing
            PEDOT:PSS, a popular conducting polymer material, faces   them  to  operate  autonomously  and extend  their
            several challenges that limit its widespread use in various   operational lifetimes.
            applications. The primary issues include the inconsistent
            conductivity of  the  material  due  to environmental   (6)   Smart environments and Internet of Things (IoT).
            sensitivity, instability, and aging of PEDOT:PSS over time,   As the IoT ecosystem expands, PEDOT:PSS
            leading to decreased performance and reliability, difficulty   sensors could play a pivotal role in creating smart
            in achieving uniform and defect-free film formation,    environments. These sensors may contribute to
            low mechanical strength and flexibility, and interface   data-driven decision-making in industries, such as
            incompatibility with certain substrates and interfaces   agriculture, infrastructure  monitoring, and urban
            in electronic devices. Addressing these limitations and   planning.
            challenges is essential to enhance the performance and   (7)   Multi-parameter sensing. The  sensors capable of
            applicability of PEDOT:PSS in areas such as energy storage   simultaneous detection of multiple parameters will
            devices, flexible electronics, and biosensors. Ongoing   become more refined, allowing for a comprehensive
            research focuses on improving stability, conductivity,   understanding of complex systems and environments.
            mechanical properties, and interfacial compatibility of
            PEDOT:PSS materials to widen their practical utilization.  (8)   Biocompatible  and  implantable  sensors.
                                                                    Advancements in biocompatible materials and
               Looking ahead, the future of 3D-printed PEDOT:PSS    fabrication techniques will enable the creation of
            hydrogel sensors holds promising prospects for further   PEDOT:PSS sensors for implantation within the
            expanding their functionalities and applications.       body, providing real-time monitoring of health
            Regardless of these achievements, some challenges still   conditions and therapeutic responses.
            remain.  As  technology  continues  to  advance,  several
            exciting directions emerge:                        (9)   Artificial  intelligence  integration.  Supported
                                                                    by artificial intelligence and machine learning
            (1)   Enhanced sensing modalities. Future PEDOT:PSS     algorithms, the PEDOT:PSS sensors will be able to
                 sensors are likely to encompass an even broader    process complex data patterns, thereby improving
                 spectrum of sensing modalities. This may involve the   accuracy and providing predictive insights.
                 integration of new materials, such as nanomaterials
                 and biomolecules, to enable the detection of a wider   (10)  Environmental  monitoring.  Environmental
                 range of analytes, including specific chemicals, ions,   monitoring is an important element in the
                 gases, and biomarkers.                             development of sustainable and smart cities, and
                                                                    thus, PEDOT:PSS sensors can play a role in this
            (2)   Real-time monitoring. The evolution of PEDOT:PSS   regard  by monitor environmental  factors,  such  as
                 sensors could lead to real-time, continuous        pollution, humidity, and temperature.
                 monitoring  of  various  parameters.  This  helps
                 revolutionize the healthcare sector, enabling the   Acknowledgments
                 constant tracking of health indicators and early
                 disease detection, as well as improving patient   None.
                 outcomes and preventive care.
                                                               Funding
            (3)   Wireless  connectivity.  Incorporating  wireless
                 communication capabilities into PEDOT:PSS sensors   This work was supported by the Xianning City Program
                 may allow seamless data transmission to external   of Science & Technology (No. 2022ZRKX051), Science
                 devices or cloud platforms. This can facilitate remote   Development Foundation of Hubei University of Science
                 monitoring, data analysis, and personalized feedback   & Technology (No. BK202217, 2021F005, 2021ZX14),
                 in real time.                                 Special Fund for Medical Research of Hubei University of



            Volume 10 Issue 2 (2024)                        19                                doi: 10.36922/ijb.1725
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