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International Journal of Bioprinting                                 3D-printed silicon nitride-PEEK implants































            Figure 2. Sample cages that were 3D-printed for mechanical testing. Solid (A, D), porous (B, E), and porous window (front and side views) (C, F) designs
            for PEEK (A, B, C) and Si N -PEEK (D, E, F) materials.
                            3  4

               The data demonstrated a normal distribution for the   There was no significant difference in stiffness
            majority of the groups (four out of six). According to    between PEEK and Si N -PEEK per design (Figure 3A).
                                                                                   4
                                                                                 3
            2 × 3 factorial ANOVA, design was significantly affecting   The compression stiffness of PEEK porous and porous
            the stiffness under compression (p < 0.001). The stiffness   window designs was significantly higher than that of
            of the porous design was significantly higher than the   the solid design (mean difference = 5622 and 4277 N/
            solid design (mean difference = 6185 N/mm, p < 0.001)   mm respectively, p < 0.001 for both). Similarly, for Si N -
                                                                                                            4
                                                                                                          3
            and the porous window design (mean difference = 1606   PEEK, porous and porous window designs achieved higher
            N/mm,  p  = 0.01). The stiffness of the porous window   compression stiffness than solid design (mean difference
            design was also significantly higher than the solid design   = 6748 and 4881 N/mm respectively, p < 0.001 for both)
            (mean difference = 4579 N/mm, p < 0.001). When stiffness   (Figure 3B). In addition to surpassing the 5th percentile
            was examined as a function of material, the main effect   of ultimate strength loading,  porous window designs for
                                                                                      28
            was not significant in stiffness of the cages as well as the   both PEEK and Si N -PEEK materials were tested above
                                                                                4
                                                                              3
            interaction between material and design.           50th percentile of ultimate compression strength defined
               In addition to the main effects, the group comparisons   by Peck et al.  (10,800 N) (Table  S3 in Supplementary
                                                                          28
            between  PEEK  and  Si N -PEEK  and  the  designs  were   File). Furthermore, solid and porous designs for both
                               3
                                 4
            analyzed (Figure 3).                               PEEK and Si N -PEEK materials were tested above 75th
                                                                          3
                                                                            4
            Table 1. Mechanical testing metrics calculated for cages
                             PEEK solid   PEEK porous   PEEK porous   Si N -PEEK solid  Si N -PEEK   Si N -PEEK porous
                                                                                   3
                                                                                     4
                                                                        4
                                                                                                  4
                                                                                                3
                                                                      3
                                                        window                    porous       window
             Compression stiffness   7886 ± 1771  13508 ± 918  12163 ± 388  6911 ± 1053  13659 ± 997  11791 ± 2032
             (N/mm)
             Shear stiffness    3171 ± 580  4052 ± 1291  3793 ± 1011  4482 ± 235  5501 ± 517   4587 ± 816
             (N/mm)
             Torsional stiffness   0.48 ± 0.08  0.36 ± 0.05  0.36 ± 0.04  0.60 ± 0.11  0.47 ± 0.09  0.45 ± 0.07
             (Nm/deg)
             Yield moment (N∙m)  8.27 ± 0.45  5.29 ± 0.52  4.77 ± 0.26  10.5 ± 0.60  6.90 ± 0.65  5.49 ± 1.07
             Ultimate moment   8.86 ± 0.60  5.82 ± 0.28  5.45 ± 0.13  11.4 ± 0.37  7.76 ± 0.21  6.49 ± 1.05
             (N∙m)

            Volume 10 Issue 2 (2024)                       435                                doi: 10.36922/ijb.2124
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