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International Journal of Bioprinting Supramolecular hydrogels as bioinks

3D printing method N/A N/A N/A

Application Biomedical application Biomedical application Clinical and biomedical applications

Self- healing property No Self-healable Self- healable; remoldable

Drug loading/ release No No No

Rheological/ mechanical properties Mechanical testing Non-swellable; excellent stretchability of 750–1000%; enhanced fracture strength; 90% compressive strain; fatigue and self- recovery; compressive strength: 4 MPa 85% compressibility; highest storage modulus and compressive stress at 2 wt% guar gum High tensile strength (≈ 1.2 MPa); large stretchability (≈ 1300%); outstanding compressive strengt

Reported injectability Yes Yes Yes Abbreviations: β-CD-AOI: Isocyanatoethyl acrylate-modified β-cyclodextrin; 4-PEG: Four-armed poly(ethylene glycol); 8-PEG: Eight-armed poly(ethylene glycol); A6ACA: Acryloyl-6-aminocaproic acid; AAP: Arylazopyrazole; Ad: Adamantane; AGP3: Agarose/gelatin/polypyrrole; A-TEG-Ad: 2-(2-{2-[2-(Adamantyl-1-oxy)ethoxy]ethoxy} ethoxy)ethanol acrylate; BA: Betulinic acid; CB[n]: Cucurbit[

In vitro studies In vitro adhesion stress test using porcine skin model; in vitro cytotoxicity; L929 fibroblast cells No Antimicrobial (E. coli and S. aureus) and anti- inflammatory activities; in vitro cytotoxicity assay

In vivo studies No No In vivo gel disk (5 x 1 mm) implantation study on C57BL/6 6-week-old male mice glycine-aspartic acid; ROB: Rat osteoblast; SCI: Spinal cord injury; UPy: Ureido pyrimidinone; UV: Ultraviolet.

Crosslinkage/ type Hydrophobic and quadruple H-bonding; oxime bond Borate/didiol bonds H-bond interactions between dual amide motifs

Table 1. (Continued...) Polymer/ combination HDI-Upy-HDI and amino-telechelic (C 6 H 12 , C 8 H 16 , and C 10 H 20 spacers) PEG4k and -ONH 2 - capped PEG-C8- Upy-C8-PEG copolymers 176 Borax-guar gum 177 N-acryloyl glycinamide and 1-vinyl-1,2,4- triazole 64

Volume 10 Issue 3 (2024) 24 doi: 10.36922/ijb.3223