Page 46 - IJB-10-3

International

Journal of Bioprinting

REVIEW ARTICLE
Techniques, mechanisms, and application of

3D-printed biodegradable metals for bone
regeneration

Lingxiao Wang 1,2† , Yang Liu , and Zhipeng Fan 1,3,4 *
1†
1 Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory for Tooth
Regeneration and Function Reconstruction of Oral Tissues, School of Stomatology, Beijing
Stomatological Hospital, Capital Medical University, Beijing, China
2 Department of Dental Implant Center, School of Stomatology, Beijing Stomatological Hospital,
Capital Medical University, Beijing, China
3 Beijing Laboratory of Oral Health, Capital Medical University, Beijing, China
4 Research Unit of Tooth Development and Regeneration, Chinese Academy of Medical Sciences,
Beijing, China

Abstract

Repairing severe bone defects and restoring complete bone tissue morphology
are major challenges in clinical practice. Biodegradable metals (BMs) are bioactive
materials with active degradation properties. The gradual improvement of three-
dimensional (3D) printing technology holds tremendous potential for development
and has spurred on the growing utilization of 3D-printed BM materials in the clinical
† These authors contributed equally applications of bone regeneration. In this paper, we review the application of three
to this work.
BM (magnesium, iron, and zinc) materials for use in 3D-printed bone regeneration;
*Corresponding author: define the principle of 3D-printed bone regeneration, including the method and
Zhipeng Fan
(zpfan@ccmu.edu.cn) selection of materials; and summarize the characteristics and uses of various printing
technologies and the properties, advantages, and disadvantages of BMs. Compared
Citation: Wang L, Liu Y, to traditional nondegradable implants, 3D-printed degradable metal implants
Fan Z. Techniques, mechanisms,
and application of 3D-printed have the advantages of not leaving residue, avoiding stress shielding, promoting
biodegradable metals for bone osteogenesis and vascularization, and exhibiting antimicrobial ability. In addition, we
regeneration. Int J Bioprint. summarize the clinical applications of 3D-printed BMs. 3D-printed BMs can be used
2024;10(3):2460.
doi: 10.36922/ijb.2460 not only for fracture fixation and bone defect repair but also for osteoporotic fracture
repair, cartilage repair, maxillofacial surgery, and other processes. In this article, we
Received: December 17, 2023
Accepted: January 19, 2024 discuss the advantages and limitations of the current 3D printing degradable metallic
Published Online: February 12, 2024 materials and describe future development prospects.
Copyright: © 2024 Author(s).
This is an Open Access article
distributed under the terms of the Keywords: Three-dimensional printing; Biodegradable metals; Bone regeneration;
Creative Commons Attribution Bone tissue engineering
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited.
1. Introduction
Publisher’s Note: AccScience
Publishing remains neutral with Bone tissue is widely distributed, large, structurally complex, and functionally diverse
regard to jurisdictional claims in
published maps and institutional in the human body; simultaneously, as a rare tissue with regenerative properties in
affiliations. the human body, bone tissue can be periodically regenerated through bone healing,

Volume 10 Issue 3 (2024) 38 doi: 10.36922/ijb.2460