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The arrival of commercial bioprinters – Towards 3D bioprinting revolution!

sophistication are still possible. The incorporation of References
IOT elements and possibly AI (artificial intelligence) in
future could only make the systems smarter. Integration 1. Ozbolat IT, 2015, Bioprinting scale-up tissue and organ
of a bioreactor with a bioprinter would be key for natural constructs for transplantation. Trends Biotechnol, 33(7):
maturation of printed tissue constructs. 395–400. http://dx.doi.org/10.1016/j.tibtech.2015.04.005
The most important component in the bioprinting apart 2. Murphy S and Atala A, 2014, 3D bioprinting of tissues
from the bioprinter is the bioink itself which supports and organs. Nat Biotechnol, 32(8): 773–785. http://dx.doi.
the cell growth, differentiation and proliferation leading
to maturation of the printed tissue. Several bioprinter org/10.1038/nbt.2958
companies have expanded their portfolio by selling 3. Gungor-Ozkerim P S, Inci I, Zhang Y S, et al., 2018, Bioinks
bioinks; some of these inks are well-known, well- for 3D bioprinting: An overview. Biomater Sci, 6(5): 915–
researched biomaterials while others are proprietary 946. http://dx.doi.org/10.1039/C7BM00765E
materials/formulations. This has enabled the companies 4. Mironov V, Boland T, Trusk T, et al., 2003, Organ printing:
to offer a complete solution to potential clients. Another
crucial element for the optimum function of bioprinting Computer-aided jet-based 3D tissue engineering. Trends
hardware is its harmony with the respective controlling Biotechnol, 21(4): 157–161. https://dx.doi.org/10.1016/
software. So far some of the low-cost bioprinters have S0167-7799(03)00033-7
been using open source software (e.g. Repetier-Host), 5. Holzl K, Lin S, Tytgat L, et al., 2016, Bioink properties
and this could have reliability issues. Going forward, before, during and after 3D bioprinting. Biofabrication, 8(3):
the printer having the most dedicated hardware-software 032002. https://doi.org/10.1088/1758-5090/8/3/032002
integration would have the edge over the rest. With
so many companies already jostling for space in this 6. Choudhury D, Tun H W, Wang T, et al., 2018, Organ-
bioprinting business, coming decade is bound to see derived decellularized extracellular matrix: A game changer
more intense competitions with the launch of upgraded for bioink manufacturing? Trends Biotechnol, https://dx.doi.
and smarter bioprinters as well as the development of org/10.1016/j.tibtech.2018.03.003
more biomimetic bioinks. Whether these commercial 7. Moroni L, Boland T, Burdick J A, et al., 2018, Biofabrication:
bioprinters get upgraded into high-throughput tissue A guide to technology and terminology. Trends
manufacturing systems, only time will tell. Whether
there will be a clear winner who is going to take the lion Biotechnol, 36(4): 384–402. https://dx.doi.org/10.1016/
share of the bioprinting device market is to be seen. The j.tibtech.2018.03.00310.1016/j.tibtech.2017.10.015
regulatory aspect also needs to keep up with the pace of 8. Atala A, Yoo J J, 2015, Essentials of 3D biofabrication and
st
the device and material development in this field. translation, 1 edition. Academic Press.
9. Chua C K, Yeong W Y, 2014, Bioprinting: Principles and
author contributions applications. 1. World Scientific Publishing Co Inc. https://
DC and MWN conceptualized the manuscript and DC, dx.doi.org/10.1142/9193
MWN and SA wrote the manuscript. DC and SA made 10. Bergin J, 2016, Bioprinting: Technologies and global
the figures and tables. MWN edited the manuscript.
markets, BCC Research, USA.
Conflict of Interest 11. 3D Bioprinting market size, share & trends analysis report by
All authors reported no conflict of interest. technology (Magnetic levitation, inkjet based, syringe based,
laser based), by application, and segment forecasts, 2018–
Funding 2024, 2018. Avaliable from: https://www.grandviewresearch.
The authors would like to thank the funding support com/industry-analysis/3d-bioprinting-market
to Bio-Manufacturing Programme (BMP) given by 12. Hornick J F, Rajan K, 2016, The 3D bioprinting patent
A*STAR, Singapore. DC and MWN are A*STAR landscape takes shape as IP leaders emerge. Avaliable from:
employees.
http://3dprintingindustry.com/news/3d-bioprinting-patent-
acknowledgments landscape-takes-shape-ip-leaders-emerge-84541/
The authors would like to sincerely thank the bioprinting 13. Rodríguez-Salvador M, Rio-Belver R M, Garechana-
companies for providing high-resolution pictures of their Anacabe G, 2017, Scientometric and patentometric analyses
bioprinters. to determine the knowledge landscape in innovative

technologies: The case of 3D bioprinting. PLOS ONE, 12(6):

16 International Journal of Bioprinting (2018)–Volume 4, Issue 2