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International Journal of Bioprinting Bioprinting hearing loss treatment

the aforementioned Corti model. Significantly, in the drug delivery scaffolds produced through 3D bioprinting
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bioprinting process of Corti organoids, the manipulation often exhibit unique geometric configurations and
of the extracellular environment and the facilitation of personalized release characteristics that can be customized
directional tissue development from stem cells are largely to address the distinct requirements of diverse patient
contingent upon the extracellular matrix, highlighting the populations. This novel administration technique is
essential contribution of exogenous bioactive factors, such characterized by its controllability, directness, and
as growth and differentiation factors. minimally invasive nature, thereby augmenting the
accuracy and efficacy of therapeutic interventions.
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Moreover, in the treatment of SD, corticosteroids are
frequently administered through the tympanic membrane. Figure 4 illustrates the role of 3D bioprinting in
However, the existing method of injection relies on sensorineural deafness management.
passive diffusion through the round window membrane, 4. Discussion
potentially resulting in drug loss via the Eustachian
tube. As a result, the extent to which therapeutic agents In contrast to conventional 3D printing methods,
reach the cochlea is frequently ambiguous. Jaffredo et bioprinting utilizes bioinks comprising liquid biomaterials,
al. investigated intracochlear administration through seed cells, and essential active factors. By precisely
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laser-assisted bioprinting (LAB), a method that permits depositing these bioinks in layers, bioprinting can directly
precise, non-invasive, and controlled drug delivery. This fabricate complex structures consisting of cells and
approach facilitates the targeted deposition of drugs such biological materials. 79,80 This technique enables precise
as dexamethasone onto a recipient substrate, namely the spatial control and the generation of structures with
perilymph, thereby ensuring optimal diffusion without tailored morphologies, highlighting the notable advantages
compromising normal auditory function. Furthermore, of bioprinting. 81
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Figure 4. 3D bioprinting in sensorineural deafness management. Abbreviation: GelMA/SA: gelatin methacryloyl/sodium alginate.

Volume 10 Issue 4 (2024) 111 doi: 10.36922/ijb.3497