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International Journal of Bioprinting 3D-Printed scaffolds for diabetic bone defects

regeneration; therefore, we used an animal model Resources: Hanfeng Yang, Jiangtao He, Lu Chen,
consistent with previous related studies. 5,45,46 Yongfu Xiong
(ii) In the future, multifactorial animal models of Writing – original draft: Caiping Yan, Ke Jiang
diabetic critical bone defects that are more in line Writing – review & editing: Yuling Li, Wei Huang,
with clinical realities should be comprehensively Dianming Jiang
considered and constructed.
Ethics approval and consent to participate
5. Conclusion All animal experiments involved in this study were
In this study, we designed a peptide-functionalized modified approved by the Ethics Committee of the Animal
3D-printed PCL porous scaffold (PCL@SS31@E7) and Experimentation Centre of Chongqing Medical University
showed that it could be used to achieve normal bone growth (IACUC-CQMU-2022-0022).
and regulation of metabolism in the region of diabetic bone
defects by recruiting BMSCs and modulating mitochondrial Consent for publication
function in a high-glucose microenvironment, resulting in Not applicable.
normal bone tissue regeneration. The results of this study
provide a new approach for the treatment of bone defects Availability of data
in diabetic patients and emphasize that modulation of
MRC function is an important part of the treatment of The datasets used and analyzed during the present study
diabetes-related diseases. can be obtained from the corresponding author upon
reasonable request.
Acknowledgments References

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Conflict of interest doi: 10.1016/j.bioactmat.2020.08.030

The authors declare no conflicts of interest. 6. Yin M, Zhang Y, Yu H, Li X. Role of hyperglycemia in the
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Author contributions doi: 10.3389/fcell.2021.665412
Conceptualization: Yuling Li, Wei Huang, Dianming Jiang 7. Ali D, Tencerova M, Figeac F, Kassem M, Jafari A. The
Methodology: Ke Jiang, Caiping Yan, Pengrui Zhang, pathophysiology of osteoporosis in obesity and type 2
Yongfu Xiong, Weikang Zhao diabetes in aging women and men: the mechanisms and

Volume 10 Issue 4 (2024) 219 doi: 10.36922/ijb.2379