Page 191 - IJB-10-5

International

Journal of Bioprinting

RESEARCH ARTICLE
Biomimetic structural design and performance

study of 3D-printed graded minimal surface
bone scaffolds with enhanced bioactivity

Tang Liu 1† id , Yuxin Lin 1† id , Lin Sang 2 id , Fei Wang 1 id , Jiawei Hu 1 id , Kun Guo 3 id ,
Shanglian Ju *, Yiping Zhao * , and Xiaohong Shu 5 id
4
1 id
1 Department of Radiology, The Second Affiliated Hospital of Dalian Medical University, Dalian,
Liaoning, China
2 School of Materials Science and Engineering, Dalian University of Technology, Dalian, Liaoning,
China
3
Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian,
Liaoning, China
4 Department of Orthopedics, The Second Affiliated Hospital of Dalian Medical University, Dalian,
Liaoning, China
5 College of Pharmacy, Dalian Medical University, Dalian, Liaoning, China

Abstract

Bone bionics and structural engineering have played a vital role in bone regeneration,
† These authors contributed equally with artificial scaffolds generating widespread interest. However, the mechanical
to this work. properties and bone regeneration potential of biomimetic structures remain unclear.
*Corresponding authors: Herein, biodegradable polymer composites based on poly(butylene adipate-co-
Shanglian Ju terephthalate)/poly(lactic acid) (PBAT/PLA) were 3D-printed into lattice structures
(jushanglian@163.com) as tissue engineering scaffolds. For structural design, graded diamond (D) minimal
Yiping Zhao surfaces were proposed and designed to mimic the natural bone structure. The
(yipizhao1975@dmu.edu.cn)
graded topologies were realized by designing gradient thickness either radially
Citation: Liu T, Lin Y, Sang L, from center to edge or vertically from top to bottom. The mechanical performance
et al. Biomimetic structural of these graded samples displayed better load-carrying and energy absorption
design and performance
study of 3D-printed graded capacity than the uniform counterparts. No obvious damage was detected in the
minimal surface bone scaffolds internal microstructure of the compressed samples using computed tomography.
with enhanced bioactivity. Subsequently, platelet-rich plasma (PRP), containing diverse cytokines, was loaded
Int J Bioprint. 2024;10(5):3416.
doi: 10.36922/ijb.3416 on the graded scaffolds. The PRP-loaded D-scaffold reported improved in vitro cell
proliferation and osteoblast differentiation. Finally, femoral condyle defect repair
Received: April 12, 2024
Accepted: May 21, 2024 results indicated that the PRP-loaded D-scaffold effectively promoted early-stage
Published Online: July 1, 2024 bone regeneration. Overall, this work provides insights into fabricating artificial
Copyright: © 2024 Author(s). scaffolds with bioactive factors and biomimetic lattice structures.
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution Keywords: Biomimetic structural design; Mechanical properties;
License, permitting distribution, Computed tomography; Bone scaffolds; Platelet-rich plasma
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with 1. Introduction
regard to jurisdictional claims in
published maps and institutional Lattice structures, possessing continuous and interconnected open pores, have
1–3
affiliations. garnered great interest in artificial materials and biological systems. Periodic

Volume 10 Issue 5 (2024) 183 doi: 10.36922/ijb.3416