Page 9 - IJB-10-5

International

Journal of Bioprinting

REVIEW ARTICLE
Advancements in 3D bioprinting for nanoparticle

evaluation: Techniques, models, and biological
applications

Moon Sup Yoon , Jae Min Lee , Min Jeong Jo , Su Jeong Kang ,
1
2
1†
1†
Myeong Kyun Yoo , So Yeon Park , Ji-Hyun Kang , Chan-Su Park 1 id ,
1
1
3
Chun-Woong Park 1 id , Jin-Seok Kim , Andrea Bernardos 5,6,7,8 id ,
4
Vicente Martí-Centelles 5,6,8 id 5,6,7,8,9 id
* , Ramón Martínez-Máñez
* ,
and Dae Hwan Shin 1,5,10*
1 College of Pharmacy, Chungbuk National University, 28160 Cheongju, Republic of Korea
2 Department of Oncology Science, University of Oklahoma, Oklahoma City, 73104 Oklahoma,
United States of America
3 Institute of New Drug Development and Respiratory Drug Development Research Institute, School
of Pharmacy, Jeonbuk National University, 54896 Jeonju, Republic of Korea
4 Drug Information Research Institute (DIRI), College of Pharmacy, Sookmyung Women’s University,
04310 Seoul, Republic of Korea
5 Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico
(IDM), Universitat Politècnica de València, Universitat de València, Camino de Vera, s/n, 46022
Valencia, Spain
† These authors contributed equally 6 CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos
to this work. III, 46026 Madrid, Spain
*Corresponding authors: 7 Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina,
Vicente Martí-Centelles Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, Avenida Eduardo
(vimarce1@upv.es) Primo Yúfera, 3, 46012 Valencia, Spain
Ramón Martínez-Máñez 8 Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022
(rmaez@qim.upv.es) Valencia, Spain
Dae Hwan Shin 9 Unidad Mixta de Investigación en Nanomedicina y Sensores, Universitat Politècnica de València,
(dshin@chungbuk.ac.kr) Instituto de Investigación Sanitaria La Fe (IISLAFE), Avenida Fernando Abril Martorell, 106, 46026
Citation: Yoon MS, Lee JM, Valencia, Spain
Jo MJ, et al. Advancements in 10 Chungbuk National University Hospital, Chungbuk National University, 28644 Cheongju,
3D bioprinting for nanoparticle Republic of Korea
evaluation: Techniques, models,
and biological applications. (This article belongs to the Special Issue: Advances in Bioprinting and Organ-on-a-chip and Applications for
Int J Bioprint. 2024;10(5):4273. Precision Medicine)
doi: 10.36922/ijb.4273
Received: July 17, 2024 Abstract
Revised: August 6, 2024
Accepted: August 7, 2024
Published Online: August 9, 2024 Three-dimensional (3D) bioprinting technology has opened new possibilities for
nanoparticle evaluation. This review discusses the latest research trends using
Copyright: © 2024 Author(s).
This is an Open Access article various disease models created through 3D bioprinting for the biological evaluation
distributed under the terms of the of nanoparticles. The focus is on tumor models, vascular models, and skin models. In
Creative Commons Attribution tumor models, evaluations include antitumor effects, gene expression analysis, and
License, permitting distribution,
and reproduction in any medium, cytotoxicity comparisons between 2D and 3D models. Vascular models are used to
provided the original work is assess restenosis prevention, ischemic repair, and vascular regeneration. Skin models
properly cited. are employed to investigate nanoparticle toxicity, drug release, and transdermal
Publisher’s Note: AccScience penetration. These studies highlight the versatility of 3D bioprinting in replicating
Publishing remains neutral with complex biological environments, enabling more accurate nanoparticle testing. The
regard to jurisdictional claims in
published maps and institutional use of various bioinks and cell types enhances the relevance of in vitro findings. The
affiliations. integration of nanoparticles with 3D-bioprinted models shows significant potential

Volume 10 Issue 5 (2024) 1 doi: 10.36922/ijb.4273