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           This work was supported by the Russian Science          Pathogenesis  of  COVID-19,  MERS,  and  SARS  in  a
           Foundation (18-15-00407, Introduction and Section       Nonhuman Primate Model. Science, 368(6494):1012–5.
           4.1), Russian Foundation for Basic Research (18-    7.   Lutz C, Maher L, Lee C, et al., 2020, COVID-19 Preclinical
                                                                   Models:  Human  Angiotensin-Converting  Enzyme  2
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           Conflict of interest                                    SARS-CoV-2 Infections in Engineered Human Tissues Using
                                                                   Clinical-Grade Soluble Human ACE2. Cell, 181(4):905–13.
           The authors declare that they have no conflict of       DOI: 10.1016/j.cell.2020.04.004.
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           Author contributions                                    Med, 9(5):548–53. DOI: 10.1038/nm860.

           A.Sh., E.G., V.M., and P.S. outlined the manuscript.   10.  DeVincenzo JP, Wilkinson T, Vaishnaw A, et al., 2010, Viral
           P.B. and M.P. contributed to Section 2.3 and 3 (except   Load  Drives  Disease  in  Humans  Experimentally  Infected
           3.2), D.B. – Section 2.1, N.K. – Section 2.2, M.V.,     with  Respiratory  Syncytial  Virus.  Am J Respir Crit Care
           E.Z., and N.K.R. – Section 3.2, and A.S. – Section      Med, 182(10):1305–14. DOI: 10.1164/rccm.201002-0221oc.
           4 and 5, A.Sv. – Section 1 and 2.3. I.Z. drafted and   11.  Memoli  MJ,  Shaw  PA,  Han A,  et al.,  2016,  Evaluation  of
           prepared Figure 3, including its description; D.B.,     Antihemagglutinin  and  Antineuraminidase  Antibodies  as
           E.Z., and N.K.R. – Figures 1 and 2. A.S. drafted the    Correlates  of  Protection  in  an  Influenza  A/H1N1  Virus
           manuscript with primary editing and revision support    Healthy  Human  Challenge  Model.  MBio,  7(2):1–12.  DOI:
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           E.G., and N.K.R. prepared the paper’s revision to   12.  Wilkinson  TM,  Li  CK,  Chui  CS,  et  al.,  2012,  Preexisting
           address reviewers’ comments. A.Sv., P.S., and E.G.      Influenza-Specific  CD4  +  T  Cells  Correlate  with  Disease
           coordinated the manuscript preparation. All authors     Protection against Influenza Challenge in Humans. Nat Med,
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