Page 290 - IJB-10-6

International

Journal of Bioprinting

RESEARCH ARTICLE
3D-printed zinc/magnesium-doped

hydroxyapatite-polycaprolactone composite
scaffolds for angiogenesis and osteogenesis

Lei Qiang 1,2,3,4 id , Hao Huang , Jing Shan , Guanlu Shen , Quan Zhang , Weize
6
6
2
5
Kong , Ya Fang , Yiwei Zhang , Jinwu Wang 4 id , Yihao Liu * , Chengwei Wang * ,
4
4
6
4 id
4 id
Pengfei Zheng * , and Jie Weng *
3,6 id
1,2 id
1 Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu,
Sichuan, China
2 Key Laboratory of Advanced Technologies of Materials (MOE), School of Materials Science and
Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, China
3
Department of Orthopaedic Surgery, Children’s Hospital of Nanjing Medical University, Nanjing,
Jiangsu, China
4 Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery Shanghai
Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
5 Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, Australia
6 Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu
Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound
Screening, Jiangsu Ocean University, Lianyungang, Jiangsu, China
*Corresponding authors:
Jie Weng (This article belongs to the Special Issue: Advances in Bioprinting and Organ-on-a-chip and Applications for
(jweng@swjtu.edu.cn) Precision Medicine)
Pengfei Zheng
(zhengpengfei@njmu.edu.cn)
Chengwei Wang Abstract
(wangcw_1222@163.com)
Yihao Liu Critical-sized bone defect repair remains a major clinical challenge that requires
(lyh19950227sjtu@sjtu.edu.cn) scaffolds with angiogenesis and osteogenesis potential. Herein, we synthesized
zinc (Zn)-doped and zinc/magnesium (Zn/Mg)-co-doped hydroxyapatite (HA) via
Citation: Qiang L, Huang H,
Shan J, et al. 3D-printed zinc/ the hydrothermal method and subsequently mixed them with polycaprolactone
magnesium-doped hydroxyapatite- (PCL) as ink to fabricate composite scaffolds through 3D printing. We explored the
polycaprolactone composite potential of composite scaffolds in promoting angiogenesis and osteogenesis. In vitro
scaffolds for angiogenesis
and osteogenesis. experiments demonstrated that Zn/Mg-co-doped composite scaffolds can promote
Int J Bioprint. 2024;10(6):4243. angiogenesis. In addition, Zn/Mg-co-doped scaffolds could promote osteogenesis
doi: 10.36922/ijb.4243 and were superior to Zn-doped composite scaffolds. Furthermore, in vivo studies
Received: July 15, 2024 using a rat femoral defect model confirmed that the Zn/Mg-co-doped scaffolds
Revised: August 27, 2024 repaired bone defects. Thus, the Zn/Mg-co-doped composite scaffolds developed
Accepted: September 3, 2024
Published Online: September 4, in this study were effective in promoting angiogenesis and bone defect repairs,
2024 providing an excellent solution for the design and development of clinical materials.
Copyright: © 2024 Author(s).
This is an Open Access article
distributed under the terms of the Keywords: Zinc/magnesium-doped hydroxyapatite-polycaprolactone scaffolds;
Creative Commons Attribution 3D printing; Angiogenesis; Osteogenesis; Bone regeneration
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited.
1. Introduction
Publisher’s Note: AccScience
Publishing remains neutral with Critical-sized bone defects, caused by trauma, bone tumors, infections, and other
regard to jurisdictional claims in
published maps and institutional diseases, cannot be self-repaired and require external intervention. Presently, the
affiliations. treatments for critical-sized bone defects repair primarily include autologous bone

Volume 10 Issue 6 (2024) 282 doi: 10.36922/ijb.4243